Abteilungs- und Gruppenleiter
Forschungsarbeit am Institut
Abteilungen des MPIIB
Rolle von Zytokinen und T-Zell Populationen bei der Immunität gegen intrazelluläre Bakterien, Regulierung und Gedächtnis bei der Immunantwort gegen intrazelluläre Bakterien, Angeborene Immunantwort gegen intrazelluläre Bakterien, Mukosale Immunität und mukosale Vakzinierung, Regulatorische RNA, Systembiologie und Tuberkulose, Systembiologie und Impfung, Rationale Impfstoff-Entwicklung gegen Tuberkulose, Biomarker der Empfänglichkeit / Resistenz bei Tuberkulose
The human mucosa constitutes the interphase between our body and the environment. Microbes that cause chronic infections and inflammation of the mucosal epithelium appear to be main drivers of malignant transformation. Yet, underlying mechanisms are sparsely understood. Our researchers are applying sophisticated means to illuminate this potentially fatal relationship between pathogen infections and their human host and aim to explore novel therapeutic strategies against cancer.
Unsere Arbeitsgruppe geht von der Hypothese aus, dass der Vielzahl von Krankheiten nur eine begrenzte Zahl von Signalwegen zugrundeliegt. Wir forschen daher an sehr verschiedenen Erkrankungen, die entweder durch eine Infektion oder einen endogenen Stimulus ausgelöst werden.
On the 1st of October of 2011, Dr. Elena A. Levashina has joined the MPIIB as a head of the new research department of Vector Biology.
Alex Sigal completed his PhD at the Weizmann Institute of Science in the field of Systems Biology, where he investigated the dynamics of cell-to-cell differences using a novel library of endogenously tagged proteins. He went on to postdoctoral training at the California Institute of Technology, where he focused on understanding the mechanisms of persistence in HIV, and specifically how directed spread of the virus by cell-to-cell contact can lead to reduced sensitivity to infection inhibitors. He joined the Kwazulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) in Durban, South Africa as an Assistant Investigator in 2012 and concurrently became a Junior Research Group Leader at the Max Planck Institute for Infection Biology.
Professor Thumbi Ndung’u was born and grew up in rural Kenya. He graduated with a degree in Veterinary Medicine from the University of Nairobi, Kenya. He obtained a PhD in Biological Sciences in Public Health from Harvard University in 2001. He then undertook postdoctoral studies in Virology at Harvard Medical School. He subsequently worked as Laboratory Director at Botswana-Harvard Partnership and is currently an Associate Professor in HIV/AIDS Research at the Nelson R Mandela School of Medicine, University of KwaZulu-Natal, South Africa. He is a past recipient of the Edgar Haber award (Harvard University), the Vice-Chancellor’s research award (University of KwaZulu-Natal) and the Friedland Senior Health Researcher Prize (South Africa). He holds the South African Research Chair in Systems Biology of HIV/AIDS, is a Howard Hughes Medical Institute International Early Career Scientist and is the K-RITH/Max Planck Investigator at the KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH).
Cells use sophisticated networks of proteins to sense and process chemical information. The Taylor Lab
investigates how these molecular networks self-organise to encode and decode information. By combining high resolution microscopy with synthetic and chemical biology approaches, we investigate this problem in the context of infection and immune cell activation. Our long-term vision is to be able to re-engineer cellular signalling systems to control cell behaviour and function.