Publications

1. Sigal A*, Baltimore D. As Good As It Gets? The Problem of HIV Persistence despite Antiretroviral Drugs. Cell Host Microbe. 2012 Aug 16;12(2):132-8. *Corresponding author.

2. Puliafito A, Hufnagel L, Neveu P, Streichan S, Sigal A, Fygenson DK, Shraiman BI. Collective and single cell behavior in epithelial contact inhibition. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):739-44.

3. Sigal A, Kim JT, Balazs AB, Dekel E, Mayo A, Milo R, Baltimore D. Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy. Nature. 2011 Sep 1;477(7362):95-8.

4. Frenkel-Morgenstern M, Cohen AA, Geva-Zatorsky N, Eden E, Prilusky J, Issaeva I, Sigal A, Cohen-Saidon C, Liron Y, Cohen L, Danon T, Perzov N, Alon U. Dynamic Proteomics: a database for dynamics and localizations of endogenous fluorescently-tagged proteins in living human cells. Nucleic Acids Res. 2009 Oct 9.

5. Cohen-Saidon C, Cohen AA, Sigal A, Liron Y, Alon U. Dynamics and Variability of ERK2 Response to EGF in Individual Living Cells. Molecular Cell. 2009 Dec 11;36(5):885-93.

6. Cohen AA, Kalisky T, Mayo A, Geva-Zatorsky N, Danon T, Issaeva I, Kopito RB, Perzov N, Milo R, Sigal A, Alon U. Protein dynamics in individual human cells: experiment and theory. PLoS One. 2009;4(4):e4901.

7. Cohen AA, Geva-Zatorsky N, Eden E, Frenkel-Morgenstern M, Issaeva I, Sigal A, Milo R, Cohen-Saidon C, Liron Y, Kam Z, Cohen L, Danon T, Perzov N, Alon U. Dynamic Proteomics of Individual Cancer Cells in Response to a Drug. Science. 2008 Dec 5;322(5907):1511-6.

8. Sigal A*, Danon T, Cohen A, Milo R, Geva-Zatorsky N, Lustig G, Liron Y, Alon U, Perzov N. Generation of a fluorescently labeled endogenous protein library in living human cells. Nat Protoc. 2007;2(6):1515-27. *Corresponding author.

9. Lavelle C, Sigal A. Systems biology meets chromatin function: a report on the Fourth Elmau Conference on Nuclear Organization. Chromosome Res. 2007;15(2):247-56.

10. Sigal A, Milo R, Cohen A, Geva-Zatorsky N, Klein Y, Liron Y, Rosenfeld N, Danon T, Perzov N, Alon U. Variability and memory of protein levels in human cells. Nature. 2006 Nov 30;444(7119):643-6.

11. Sigal A, Milo R, Cohen A, Geva-Zatorsky N, Klein Y, Alaluf I, Swerdlin N, Perzov N, Danon T, Liron Y, Raveh T, Carpenter AE, Lahav G, Alon U. Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat Methods. 2006 Jul;3(7):525-31.

12. Geva-Zatorsky N, Rosenfeld N, Itzkovitz S, Milo R, Sigal A, Dekel E, Yarnitzky T, Liron Y, Polak P, Lahav G, Alon U. Oscillations and variability in the p53 system. Mol Syst Biol. 2006;2:2006 0033.

13. Sigal A, Rotter V. The oncogenic activity of p53 mutants. Zambetti G, editor. New York: Springer; 2005.

14. Lahav G, Rosenfeld N, Sigal A, Geva-Zatorsky N, Levine AJ, Elowitz MB, Alon U. Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet. 2004 Feb;36(2):147-50.

15. Sigal A, Matas D, Almog N, Goldfinger N, Rotter V. The C-terminus of mutant p53 is necessary for its ability to interfere with growth arrest or apoptosis. Oncogene. 2001 Aug 9;20(35):4891-8.

16. Seluanov A, Gorbunova V, Falcovitz A, Sigal A, Milyavsky M, Zurer I, Shohat G, Goldfinger N, Rotter V. Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53. Mol Cell Biol. 2001 Mar;21(5):1552-64.

17. Matas D, Sigal A, Stambolsky P, Milyavsky M, Weisz L, Schwartz D, Goldfinger N, Rotter V. Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis. EMBO J. 2001 Aug 1;20(15):4163-72.

18. Sigal A, Rotter V. Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome. Cancer Res. 2000 Dec 15;60(24):6788-93.

19. Sigal A, Bleijs DA, Grabovsky V, van Vliet SJ, Dwir O, Figdor CG, van Kooyk Y, Alon R. The LFA-1 integrin supports rolling adhesions on ICAM-1 under physiological sheer flow in a permissive cellular environment. Journal of Immunology. 2000 Jul 1;165(1):442-52.

 
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