Independent Minerva Group Innate Immunity
Professional phagocytes detect microorganisms within infected tissue. During bacterial infection, multiple signals, including microbial moieties, metabolic cues and danger molecules, require processing and integration by phagocytes for controlled initiation of inflammation and for host defense with minimal collateral damage. Phagocyte versatility and crosstalk with parenchyma cells shape inflammatory patterns during infection. The focus of our group is to explore regulation of bacteria-induced inflammation at the tissue level, deciphering intercellular networking, and at the molecular level, elucidating cell-intrinsic regulation in the context of mucosal pathogens, notably in the lung.