Relevant publications

Relevant publications

Benckert J, Schmolka N, Kreschel C, Zoller MJ, Sturm A, Wiedenmann B, Wardemann H.: The majority of intestinal IgA+ and IgG+ plasmablasts in the human gut are antigen-specific. J Clin Invest. 121(5):1946-55. (2011).

Tiller T, Kofer J, Kreschel C, Busse CE, Riebel S, Wickert S, Oden F, Mertes MM, Ehlers M, Wardemann H.: Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc gammaRIIB-deficient mice. J Exp Med. 207(12):2767-78 (2010).

Mouquet, H., Scheid, J.F., Zoller, M.J., Krogsgaard, M., Ott, R.G., Shukair, S., Artyomov, M.N., Pietzsch, J., Connors, M., Pereyra, F., Walker, B.D., Ho, D.D., Wilson, P.C., Seaman, M.S., Eisen, H.N., Chakraborty, A.K., Hope, T.J., Ravetch, J.V., Wardemann, H., Nussenzweig, M.C.: Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature. 467:591-5 (2010).

Tiller, T., Busse, C.E., Wardemann, H.: Cloning and expression of murine Ig genes from single B cells. J Immunol Methods. 350:183-93 (2009).

Scheid, J.F., Maouquet, H., Feldhahn, N., Seaman, M.S., Velinzon, K., Pietzsch, J., Ott, R.G., Anthony, R.M., Zebroski, H., Hurley, A., Phogat, A., Chakrabarti, B., Li, Y., Connors, M., Pereyra, F., Walker, B.D., Wardemann, H., Ho, D., Wyatt, R.T., Mascola, J.R., Ravetch, J.V., Nussenzweig, M.C.: Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals. Nature. 458:636-40 (2009).

Scheid, J.F., Mouquet, H., Feldhahn, N., Walker, B.D., Pereyra, F., Cutrell, E., Seaman, M.S., Mascola, J.R., Wyatt, R.T., Wardemann, H., Nussenzweig, M.C.: A method for identification of HIV gp140 binding memory B cells in human blood. J Immunol Methods. 343:65-7 (2009).

Köhler, F., Hug, E., Eschbach, C., Meixlsperger, S., Hobeika, E., Kofer, J., Wardemann, H., Jumaa, H.: Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells. Immunity. 29:912-21 (2008).

Meffre, E., Wardemann, H.: B-cell tolerance checkpoints in health and autoimmunity. Curr Opin Immunol. 20:632-8 (2008).

Mietzner, B., Tsuiji, M., Scheid, J., Velinzon, K., Tiller, T., Abraham, K., Gonzalez, J.B., Pascual, V., Stichweh, D., Wardemann, H., Nussenzweig, M.C.: Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors.Proc Natl Acad Sci USA. 105:9727-32 (2008).

Tiller, T., Meffre, E., Yurasov, S., Tsuiji, M., Nussenzweig, M.C., Wardemann, H.: Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning. J. Imm. Meth. 329:112-124 (2008).

Wardemann, H., Nussenzweig, M.C.: B cell self-tolerance in humans. Adv. Immunol. 95:83-110 (2007).

Tiller T., Tsuiji, M., Yurasov, S., Velinzon, K., Nussenzweig, M.C., Wardemann, H.: Autoreactivity in human IgG+ memory B cells. Immunity. 26:205-213 (2007).

Yuroasov S., Tiller, T., Tsuiji, M., Velinzon, K., Pascual, V., Wardemann, H., Nussenzweig, M.C.: Persistent autoantibody production in SLE patients in remission. J. Exp. Med. 203:2255-2261 (2006).

Tsuiji M., Yurasov S., Velinzon K., Thomas S., Nussenzweig M.C., Wardemann H.: A checkpoint for autoreactivity in human IgM+ memory B cell development. J. Exp. Med. 203:393-400 (2006).

Yurasov S., Hammersen J., Tiller T., Tsuiji M., Wardemann H.: B-Cell Tolerance Checkpoints in Healthy Humans and Patients with Systemic Lupus Erythematosus. Ann. NY Acad Sci 1062:165-74 (2006).

Herve M., Xu K., Ng Y.S., Wardemann H., Albesiano E., Messmer B.T., Chiorazzi N., Meffre E.: Unmutated and mutated chronic lymphocytic leukemia derive from self-reactive B cell precursors despite expressing different antibody reactivity.J Clin Invest. 115:1636-1643 (2005).

Yurasov, S., Wardemann, H., Hammersen, J., Tsuiji, M., Meffre, E., Pascual, V. & Nussenzweig, M.C.: Defective B Cell Tolerance Checkpoints in Systemic Lupus Erythematosus. J. Exp. Med. 201:703-711 (2005).

Ng, Y.S., Wardemann, H., Chelnis, J., Cunningham-Rundles, C. and Meffre, E.: Bruton's Tyrosine Kinase is essential for Human B cell Tolerance. J. Exp. Med. 200:927-934 (2004).

Wardemann, H., Hammersen, J. & Nussenzweig, M.C. Human autoantibody silencing by immunoglobulin light chains. J. Exp. Med. 200:191-199 (2004).

Jankovic, M., Casellas, R., Yannoutsos, N., Wardemann, H. & Nussenzweig, M.C. Rags and regulation of autoantibodies. Annu. Rev. Immunol. 22:485-501 (2004).

Carsetti, R., Rosado, M.M. & Wardemann, H. Peripheral development of B cells in mouse and man. Immunol Rev. 197:179-91 (2004).

Meffre, E., Schaefer, A., Wardemann, H., Wilson, P., Davis, E. & Nussenzweig, M.C. Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies. J. Exp. Med. 199:145-150 (2004).

Wardemann, H., Yurasov, S, Schaefer, A., Young, J.W., Meffre, E., Nussenzweig, M. Predominant Autoantibody Production by Early Human B cell Precursors. Science 301:1374-1377 (2003).

 
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