Innate regulation of tumor-directed T cell immunity

New Voices in Infection Biology

  • Datum: 25.05.2022
  • Uhrzeit: 16:00
  • Vortragende(r): Barbara Maier
  • CeMM, Vienna
  • Ort: Zoom video conference
  • Gastgeber: Olivia Majer
  • Kontakt:
Innate regulation of tumor-directed T cell immunity

If you are interested in joining the seminar, please contact:

Once registered, you will receive a zoom conference link 30 mins before the talk starts - please sign in using your full name.

Talk abstract:

T cell polarization and effector function is largely controlled by antigen-presenting cells (APC) – dendritic cells and macrophages - , which provide key signals including direct antigen presentation and co-stimulation, cytokines, metabolites, and other small messengers and receptor-ligand interactions. In solid tumors, APC functionality is impaired by tumor-derived immunosuppressive signals, resulting in unique phenotypes of tumor-associated APC that differ from their homeostatic counterparts. We have now uncovered regulatory modules expressed by distinct tumor-associated APC; however, how these programs translate into tumor-directed T cell responses, and whether novel myeloid targets can be successfully modulated for cancer immunotherapy still needs to be explored.

Zur Redakteursansicht