Lymphocyte development from stem cells
Research report (imported) 2008 - Max Planck Institute for Infection Biology
All essential blood forming cells can be generated from the embryonic stem cells of mice and retransplanted into recipient mice. The influence of a larger number of genes with different functions during the generation of the innate and adaptive immune system can thus genetically be studied under natural conditions. Since in embryonic stem cells a defect gene can be replaced by a copy of its intact form by homologous recombination, immunodeficiencies can be repaired by targeted gene therapy.