Vector biology - a paradigm of host–pathogen interactions
Research report (imported) 2013 - Max Planck Institute for Infection Biology
Insects represent 90% of animal species in our planet. Only a small fraction is known as vectors of infectious diseases. Our work is focused on Anopheles gambiae, the most efficient vector of malaria, which kills about 600,000 people annually. What makes some insect species such a good host for Plasmodium, the parasite that causes the disease? How does the mosquito detect Plasmodium and protect itself against the pathogen? These questions are the focus of our research, which aims to understand the molecular mechanisms of mosquito resistance to Plasmodium and their role in malaria transmission.