Of Hamsters and Viruses – Different Approaches to SARS-CoV-2 Vaccination | New Voices in Infection Biology

If you are interested in joining the seminar, please contact: vseminars@mpiib-berlin.mpg.de

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Talk abstract:

During the lasts months, we have, in collaboration with many partners from industry and academia, developed and tested different approaches to SARS-CoV-2 vaccination. We identified several vaccine candidates that induce sterilizing immunity in different species of hamsters. Using a human adenovirus as vector, we compared the efficacy of different SARS-CoV-2 antigens as targets for vaccination and found major differences in the ability of these vector vaccines to protect from SARS-CoV-2 replication. More than that, we have developed life attenuated vaccines by large-scale recoding of the SARS-CoV-2 genome and identified a safe and effective vaccine candidate as promising alternative to sub-unit based vaccines.