Spatial and temporal regulation of the Type 6 Secretion System dynamics during interactions with bacterial and eukaryotic cells

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Bacteria have evolved several nanomachines to deliver proteins from their cytosol to target cells. These nanomachines differ in their structure, secrete various substrates and are often essential for bacterial survival in diverse environments. In my talk, I will describe structure, dynamics and mode of action of the bacterial Type VI secretion system (T6SS). I will show how we used a combination of live-cell imaging, cryo-electron microscopy and genetics to show that T6SS is a powerful speargun that pushes proteins across membranes of both eukaryotic and bacterial cells. I will show the latest update on our understanding of subcellular localization of T6SS assembly in various bacteria and how the use of super-resolution microcopy revealed that localization of T6SS assembly is regulated with a remarkable precision with implications for its function.