Virus-host-virus interactions: the good, the bad and the ugly
Voices in Infection Biology
- Date: May 24, 2023
- Time: 04:00 PM (Local Time Germany)
- Speaker: Pablo Murcia
- Medical Research Council - University of Glasgow Centre for Virus Research
- Location: Max Planck Institute for Infection Biology and via Zoom
- Room: seminar room 1+2
- Host: Matthieu Domenech de Cellès
- Contact: vseminars@mpiib-berlin.mpg.de
If you are interested in joining the seminar, please contact: vseminars@mpiib-berlin.mpg.de. You will receive an automatic reply containing the Zoom link for the seminar.
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The study of viruses is commonly focused on a one virus/one disease approach, where susceptibility, virulence, and transmission are defined by virus-host interactions. In recent years we have followed a multi-virus, multi-scale approach that has opened a space for discovery of novel virus-virus interactions and has the potential to produce a step change in the fundamental understanding of infection biology. Using respiratory viruses as a model system, I will discuss the processes that mediate virus-virus interactions and their consequences at the cellular, individual and population scale. I will show published and unpublished data describing how viruses use the host innate and adaptive immune response against taxonomically related and unrelated viruses. I will also describe the generation of hybrid viruses by coinfections, and their potential implications regarding virus pathogenesis.