Publications
1. Morrison, S.J., Uchida, N., and Weissman, I.L. The biology of hematopoietic stem cells. Annu Rev Cell Dev Biol, 1995. 11: p. 35-71.
2. Spangrude, G.J., Smith, L., Uchida, N., Ikuta, K., Heimfeld, S., Friedman, J., and Weissman, I.L. Mouse hematopoietic stem cells. Blood, 1991. 78(6): p. 1395-402.
3. Orkin, S.H. GATA-binding transcription factors in hematopoietic cells. Blood, 1992. 80(3): p. 575-81.
4. Tsai, F.Y., Keller, G., Kuo, F.C., Weiss, M., Chen, J., Rosenblatt, M., Alt, F.W., and Orkin, S.H. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature, 1994. 371(6494): p. 221-6.
5. Scott, E.W., Simon, M.C., Anastasi, J., and Singh, H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science, 1994. 265(5178): p. 1573-7.
6. Singh, H. Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates. Curr Opin Immunol, 1996. 8(2): p. 160-5.
7. Georgopoulos, K., Bigby, M., Wang, J.H., Molnar, A., Wu, P., Winandy, S., and Sharpe, A. The Ikaros gene is required for the development of all lymphoid lineages. Cell, 1994. 79(1): p. 143-56.
8. Wang, J.H., Nichogiannopoulou, A., Wu, L., Sun, L., Sharpe, A.H., Bigby, M., and Georgopoulos, K. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity, 1996. 5(6): p. 537-49.
9. Lin, H. and Grosschedl, R. Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature, 1995. 376(6537): p. 263-7.
10. Bain, G., Maandag, E.C., Izon, D.J., Amsen, D., Kruisbeek, A.M., Weintraub, B.C., Krop, I., Schlissel, M.S., Feeney, A.J., van Roon, M., van der Valk, M., te Riele, H.P.J., Berns, A., and Murre, C. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell, 1994. 79(5): p. 885-92.
11. Zhuang, Y., Soriano, P., and Weintraub, H. The helix-loop-helix gene E2A is required for B cell formation. Cell, 1994. 79(5): p. 875-84.
12. Rolink, A.G., Schaniel, C., Busslinger, M., Nutt, S.L., and Melchers, F. Fidelity and infidelity in commitment to B-lymphocyte lineage development. Immunol Rev, 2000. 175: p. 104-11.
13. Melchers, F. and Rolink, A.G. B-Lymphocyte Development and Biology. In: Fundamental Immunology. (ed.: W.E. Paul) 1999, Lippincott-Raven Publishers: Philadelphia. p. 183-224.
14. Melchers, F. and Kincade, P. Early B cell development to a mature, antigen-sensitive cell. In: Molecular Biology of B Cells. (eds.: F.W. Alt, T. Honjo, M. Neuberger) 2004, Academic Press.
15. Rolink, A., Ghia, P., Grawunder, U., Haasner, D., Karasuyama, H., Kalberer, C., Winkler, T., and Melchers, F. In-vitro analyses of mechanisms of B-cell development. Semin Immunol, 1995. 7(3): p. 155-67.
16. Rolink, A., Kudo, A., Karasuyama, H., Kikuchi, Y., and Melchers, F. Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo. Embo J, 1991. 10(2): p. 327-36.
17. Hardy, R.R., Shinton, S.A., and Hayakawa, K. Repopulation of SCID mice with fetal-derived B-lineage cells. Curr Top Microbiol Immunol, 1992. 182: p. 73-80.
18. Nutt, S.L., Urbanek, P., Rolink, A., and Busslinger, M. Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus. Genes Dev, 1997. 11(4): p. 476-91.
19. Nutt, S.L., Heavey, B., Rolink, A.G., and Busslinger, M. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature, 1999. 401(6753): p. 556-62.
20. Schaniel, C., Gottar, M., Roosnek, E., Melchers, F., and Rolink, A.G. Extensive in vivo self-renewal, long-term reconstitution capacity, and hematopoietic multipotency of Pax5-deficient precursor B-cell clones. Blood, 2002. 99(8): p. 2760-6.
21. Rolink, A., Nutt, S., Busslinger, M., ten Boekel, E., Seidl, T., Andersson, J., and Melchers, F. Differentiation, dedifferentiation, and redifferentiation of B-lineage lymphocytes: roles of the surrogate light chain and the Pax5 gene. Cold Spring Harb Symp Quant Biol, 1999. 64: p. 21-5.
22. Rolink, A.G., Nutt, S.L., Melchers, F., and Busslinger, M. Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors. Nature, 1999. 401(6753): p. 603-6.
23. Schaniel, C., Bruno, L., Melchers, F., and Rolink, A.G. Multiple hematopoietic cell lineages develop in vivo from transplanted Pax5-deficient pre-B I-cell clones. Blood, 2002. 99(2): p. 472-8.
24. Senju, S., Hirata, S., Matsuyoshi, H., Masuda, M., Uemura, Y., Araki, K., Yamamura, K., and Nishimura, Y. Generation and genetic modification of dendritic cells derived from mouse embryonic stem cells. Blood, 2003. 101(9): p. 3501-8.
25. Schmitt, T.M., de Pooter, R.F., Gronski, M.A., Cho, S.K., Ohashi, P.S., and Zuniga-Pflucker, J.C. Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro. Nat Immunol, 2004. 5(4): p. 410-7.
26. Hoffmann, R., Seidl, T., Neeb, M., Rolink, A., and Melchers, F. Changes in gene expression profiles in developing B cells of murine bone marrow. Genome Res, 2002. 12(1): p. 98-111.
27. Melchers, F. Fit for life in the immune system? Surrogate L chain tests H chains that test L chains. Proc Natl Acad Sci U S A, 1999. 96(6): p. 2571-3.
28. Shimizu, T., Mundt, C., Licence, S., Melchers, F., and Martensson, I.L. VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus. J Immunol, 2002. 168(12): p. 6286-93.
29. Ohnishi, K. and Melchers, F. The nonimmunoglobulin portion of lambda5 mediates cell-autonomous pre-B cell receptor signaling. Nat Immunol, 2003. 4(9): p. 849-56.