Publications
2021
Plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes.
Thomson-Luque R, Votborg-Novél L, Ndovie W, Andrade CM, Niangaly M, Attipa C, Lima NF, Coulibaly D, Doumtabe D, Guindo B, Tangara B, Maiga F, Kone AK, Traore K, Kayentao K, Ongoiba A, Doumbo S, Thera MA, Traoré B, Seydel K, Osório NS, Portugal S.
Nat Commun. 2021 Jul 30;12(1):4711. doi: 10.1038/s41467-021-25062-z.
PMID: 34330920
Plasmodium falciparum-specific IgM B cells dominate in children, expand with malaria, and produce functional IgM.
Hopp CS, Sekar P, Diouf A, Miura K, Boswell K, Skinner J, Tipton CM, Peterson ME, Chambers MJ, Andrews S, Lu J, Tan J, Li S, Doumbo S, Kayentao K, Ongoiba A, Traore B, Portugal S, Sun PD, Long C, Koup RA, Long EO, McDermott AB, Crompton PD.
J Exp Med. 2021 Apr 5;218(4):e20200901. doi: 10.1084/jem.20200901.
PMID: 33661303
Multimeric antibodies from antigen-specific human IgM+ memory B cells restrict Plasmodium parasites.
Thouvenel CD, Fontana MF, Netland J, Krishnamurty AT, Takehara KK, Chen Y, Singh S, Miura K, Keitany GJ, Lynch EM, Portugal S, Miranda MC, King NP, Kollman JM, Crompton PD, Long CA, Pancera M, Rawlings DJ, Pepper M.
J Exp Med. 2021 Apr 5;218(4):e20200942. doi: 10.1084/jem.20200942.
PMID: 33661302
2020
Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season.
Andrade CM, Fleckenstein H, Thomson-Luque R, Doumbo S, Lima NF, Anderson C, Hibbert J, Hopp CS, Tran TM, Li S, Niangaly M, Cisse H, Doumtabe D, Skinner J, Sturdevant D, Ricklefs S, Virtaneva K, Asghar M, Homann MV, Turner L, Martins J, Allman EL, N'Dri ME, Winkler V, Llinás M, Lavazec C, Martens C, Färnert A, Kayentao K, Ongoiba A, Lavstsen T, Osório NS, Otto TD, Recker M, Traore B, Crompton PD, Portugal S.
Nat Med. 2020 Dec;26(12):1929-1940. doi: 10.1038/s41591-020-1084-0. Epub 2020 Oct 26.
PMID: 33106664
2019
A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation. Tran TM, Guha R, Portugal S, Skinner J, Ongoiba A, Bhardwaj J, Jones M, Moebius J, Venepally P, Doumbo S, DeRiso EA, Li S, Vijayan K, Anzick SL, Hart GT, O'Connell EM, Doumbo OK, Kaushansky A, Alter G, Felgner PL, Lorenzi H, Kayentao K, Traore B, Kirkness EF, Crompton PD. Immunity. 2019 Aug 23. pii: S1074-7613(19)30335-8. PMID: 31492649
Binding brain better-matching var genes and endothelial receptors. Fleckenstein H, Portugal S. EMBO Mol Med. 2019 Feb 25. pii: e10137. PMID: 30804082
2017
Malaria-induced interferon-γ drives the expansion of Tbethi atypical memory B cells. Obeng-Adjei N, Portugal S, Holla P, Li S, Sohn H, Ambegaonkar A, Skinner J, Bowyer G, Doumbo OK, Traore B, Pierce SK, Crompton PD. PLoS Pathog. 2017 Sep 27;13(9):e1006576. PMID: 28953967
Atypical memory B cells in human chronic infectious diseases: An interim report. Portugal S, Obeng-Adjei N, Moir S, Crompton PD, Pierce SK. Cell Immunol. 2017 Nov;321:18-25. Review. PMID: 28735813
Treatment of Chronic Asymptomatic Plasmodium falciparum Infection Does Not Increase the Risk of Clinical Malaria Upon Reinfection. Portugal S, Tran TM, Ongoiba A, Bathily A, Li S, Doumbo S, Skinner J, Doumtabe D, Kone Y, Sangala J, Jain A, Davies DH, Hung C, Liang L, Ricklefs S, Homann MV, Felgner PL, Porcella SF, Färnert A, Doumbo OK, Kayentao K, Greenwood BM, Traore B, Crompton PD. Clin Infect Dis. 2017 Mar 1;64(5):645-653. PMID: 28362910
2016
Targeting Neutrophils to Prevent Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome in Mice. Sercundes MK, Ortolan LS, Debone D, Soeiro-Pereira PV, Gomes E, Aitken EH, Condino-Neto A, Russo M, D' Império Lima MR, Alvarez JM, Portugal S, Marinho CR, Epiphanio S. PLoS Pathog. 2016 Dec 7;12(12):e1006054. PMID: 27926944
Somatically Hypermutated Plasmodium-Specific IgM(+) Memory B Cells Are Rapid, Plastic, Early Responders upon Malaria Rechallenge. Krishnamurty AT, Thouvenel CD, Portugal S, Keitany GJ, Kim KS, Holder A, Crompton PD, Rawlings DJ, Pepper M. Immunity. 2016 Aug 16;45(2):402-14. PMID: 27473412
2015
Circulating Th1-Cell-type Tfh Cells that Exhibit Impaired B Cell Help Are Preferentially Activated during Acute Malaria in Children. Obeng-Adjei N, Portugal S, Tran TM, Yazew TB, Skinner J, Li S, Jain A, Felgner PL, Doumbo OK, Kayentao K, Ongoiba A, Traore B, Crompton PD. Cell Rep. 2015 Oct 13;13(2):425-39. PMID: 26440897
Genetic Resistance to Malaria Is Associated With Greater Enhancement of Immunoglobulin (Ig)M Than IgG Responses to a Broad Array of Plasmodium falciparum Antigens. Arama C, Skinner J, Doumtabe D, Portugal S, Tran TM, Jain A, Traore B, Doumbo OK, Davies DH, Troye-Blomberg M, Dolo A, Felgner PL, Crompton PD. Open Forum Infect Dis. 2015 Aug 26;2(3):ofv118. Sep. PMID: 26361633
Malaria Vaccines: Moving Forward After Encouraging First Steps. Tran TM, Portugal S, Draper SJ, Crompton PD. Curr Trop Med Rep. 2015 Mar;2(1):1-3. PMID: 25995985
Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function. Portugal S, Tipton CM, Sohn H, Kone Y, Wang J, Li S, Skinner J, Virtaneva K, Sturdevant DE, Porcella SF, Doumbo OK, Doumbo S, Kayentao K, Ongoiba A, Traore B, Sanz I, Pierce SK, Crompton PD. Elife. 2015 May 8;4. PMID: 25955968
HIV Malaria Co-Infection Is Associated with Atypical Memory B Cell Expansion and a Reduced Antibody Response to a Broad Array of Plasmodium falciparum Antigens in Rwandan Adults. Subramaniam KS, Skinner J, Ivan E, Mutimura E, Kim RS, Feintuch CM, Portugal S, Anastos K, Crompton PD, Daily JP. PLoS One. 2015 Apr 30;10(4):e0124412. PMID: 25928218
Impact of acute malaria on pre-existing antibodies to viral and vaccine antigens in mice and humans. Banga S, Coursen JD, Portugal S, Tran TM, Hancox L, Ongoiba A, Traore B, Doumbo OK, Huang CY, Harty JT, Crompton PD. PLoS One. 2015 Apr 28;10(4):e0125090. PMID: 25919588
2014
Gut microbiota elicits a protective immune response against malaria transmission. Yilmaz B, Portugal S, Tran TM, Gozzelino R, Ramos S, Gomes J, Regalado A, Cowan PJ, d'Apice AJ, Chong AS, Doumbo OK, Traore B, Crompton PD, Silveira H, Soares MP. Cell. 2014 Dec 4;159(6):1277-89. PMID: 25480293
Exposure-dependent control of malaria-induced inflammation in children. Portugal S, Moebius J, Skinner J, Doumbo S, Doumtabe D, Kone Y, Dia S, Kanakabandi K, Sturdevant DE, Virtaneva K, Porcella SF, Li S, Doumbo OK, Kayentao K, Ongoiba A, Traore B, Crompton PD. PLoS Pathog. 2014 Apr 17;10(4):e1004079. PMID: 24743880
Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease. Crompton PD, Moebius J, Portugal S, Waisberg M, Hart G, Garver LS, Miller LH, Barillas-Mury C, Pierce SK. Annu Rev Immunol. 2014;32:157-87. Review. PMID: 24655294
2013
11. Young lives lost as B cells falter: what we are learning about antibody responses in malaria. Portugal S, Pierce SK, Crompton PD. J Immunol. 2013 Apr 1;190(7):3039-46. Review. PMID: 23526829
2012
B cell analysis of ethnic groups in Mali with differential susceptibility to malaria. Portugal S, Doumtabe D, Traore B, Miller LH, Troye-Blomberg M, Doumbo OK, Dolo A, Pierce SK, Crompton PD. Malar J. 2012 May 11;11:162. PMID: 22577737
2011
Superinfection in malaria: Plasmodium shows its iron will. Portugal S, Drakesmith H, Mota MM. EMBO Rep. 2011 Dec 1;12(12):1233-42. Review. PMID: 22081142
Host-mediated regulation of superinfection in malaria. Portugal S, Carret C, Recker M, Armitage AE, Gonçalves LA, Epiphanio S, Sullivan D, Roy C, Newbold CI, Drakesmith H, Mota MM. Nat Med. 2011 Jun;17(6):732-7. doi: 10.1038/nm.2368. Epub 2011 May 15. PMID: 21572427
2010
Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection. Dowling DP, Ilies M, Olszewski KL, Portugal S, Mota MM, Llinás M, Christianson DW. Biochemistry. 2010 Jul 6;49(26):5600-8. PMID: 20527960
2008
Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection. Rodrigues CD, Hannus M, Prudêncio M, Martin C, Gonçalves LA, Portugal S, Epiphanio S, Akinc A, Hadwiger P, Jahn-Hofmann K, Röhl I, van Gemert GJ, Franetich JF, Luty AJ, Sauerwein R, Mazier D, Koteliansky V, Vornlocher HP, Echeverri CJ, Mota MM. Cell Host Microbe. 2008 Sep 11;4(3):271-82. PMID: 18779053
Genistein-supplemented diet decreases malaria liver infection in mice and constitutes a potential prophylactic strategy. Cunha-Rodrigues M, Portugal S, Prudêncio M, Gonçalves LA, Casalou C, Buger D, Sauerwein R, Haas W, Mota MM. PLoS One. 2008 Jul 16;3(7):e2732. PMID: 18628947
Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection. Epiphanio S, Mikolajczak SA, Gonçalves LA, Pamplona A, Portugal S, Albuquerque S, Goldberg M, Rebelo S, Anderson DG, Akinc A, Vornlocher HP, Kappe SH, Soares MP, Mota MM. Cell Host Microbe. 2008 May 15;3(5):331-8. PMID: 18474360
2007
Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria. Pamplona A, Ferreira A, Balla J, Jeney V, Balla G, Epiphanio S, Chora A, Rodrigues CD, Gregoire IP, Cunha-Rodrigues M, Portugal S, Soares MP, Mota MM. Nat Med. 2007 Jun;13(6):703-10. Epub 2007 May 13. PMID: 17496899
Bone marrow chimeric mice reveal a dual role for CD36 in Plasmodium berghei ANKA infection. Cunha-Rodrigues M, Portugal S, Febbraio M, Mota MM. Malar J. 2007 Mar 16;6:32. PMID: 17367535
2006
Infection by and protective immune responses against Plasmodium berghei ANKA are not affected in macrophage scavenger receptors A deficient mice. Cunha-Rodrigues M, Portugal S, Febbraio M, Mota MM. BMC Microbiol. 2006 Aug 16;6:73. PMID: 16914051