Publications

Rael, V. E.; Yano, J. A.; Huizar, J. P.; Slayden, L. C.; Weiss, M. A.; Turcotte, E. A.; Terry, J. M.; Zuo, W.; Thiffault, I.; Farrow, T. P. E. G. et al.; Jenkins, J. L.; Becker, M. L.; Wong, S. C.; Stevens, A. M.; Otten, C.; Allenspach, E. J.; Bonner, D. E.; Bernstein, J. A.; Wheeler, M. T.; Saxton, R. A.; Undiagnosed Diseases, N.; Liu, B.; Majer, O.; Barton, G. M.: Large-scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans. Journal of experimental medicine: JEM 221 (8), e20232005 (2024)

Wolf, C.; Lim, E. L.; Mokhtari, M.; Kind, B.; Odainic, A.; Lara-Villacanas, E.; Koss, S.; Mages, S.; Menzel, K.; Engel, K. et al.; Dückers, G.; Bernbeck, B.; Schneider, D. T.; Siepermann, K.; Niehues, T.; Goetzke, C. C.; Durek, P.; Minden, K.; Dörner, T.; Stittrich, A.; Szelinski, F.; Guerra, G. M.; Massoud, M.; Bieringer, M.; de Mann, C. C. O.; Beltrán, E.; Kallinich, T.; Mashreghi, M.-F.; Schmidt, S. V.; Latz, E.; Klughammer, J.; Majer, O.; Lee-Kirsch, M. A.: UNC93B1 variants underlie TLR7-dependent autoimmunity. Science Immunology 9 (92), eadi9769 (2024)

Mishra, H.; Schlack-Leigers, C.; Lim, E. L.; Thieck, O.; Magg, T.; Raedler, J.; Wolf, C.; Klein, C.; Ewers, H.; Lee-Kirsch, M. A. et al.; Meierhofer, D.; Hauck, F.; Majer, O.: Disrupted degradative sorting of TLR7 is associated with human lupus. Science Immunology, eadi9575 (2024)

Wolf, C.; Lim, E. L.; Mokhtari, M.; Kind, B.; Odainic, A.; Lara-Villacanas, E.; Koss, S.; Mages, S.; Menzel, K.; Engel, K. et al.; Dückers, G.; Bernbeck, B.; Schneider, D. T.; Siepermann, K.; Niehues, T.; Goetzke, C. C.; Durek, P.; Minden, K.; Dörner, T.; Stittrich, A.; Szelinski, F.; Guerra, G. M.; Massoud, M.; Bieringer, M.; de Mann, C. C. O.; Beltrán, E.; Kallinich, T.; Mashreghi, M.-F.; Schmidt, S. V.; Latz, E.; Klughammer, J.; Majer, O.; Lee-Kirsch, M. A.: UNC93B1 variants underlie TLR7-dependent autoimmunity. Science Immunology, eadi9769 (2024)

Majer, O.; Liu, B.; Kreuk, L. S. M.; Krogan, N.; Barton, G. M.: UNC93B1 Recruits syntenin-1 to Dampen TLR7 Signalling and Prevent Autoimmunity. Nature 575 (7782), pp. 366 - 370 (2019)

Majer, O.; Liu, B.; Woo, B. J.; Kreuk, L. S. M.; Dis, E. V.; Barton, G. M.: Release from UNC93B1 reinforces the compartmentalized activation of select TLRs. Nature 575 (7782), pp. 371 - 374 (2019)

Majer, O.; Liu, B.; Barton, G. M.: Nucleic Acid-Sensing TLRs: Trafficking and Regulation. Current Opinion in Immunology 44, pp. 26 - 33 (2017)

Köprülü, A. D.; Kastner, R.; Wienerroither, S.; Lassnig, C.; Putz, E. M.; Majer, O.; Reutterer, B.; Sexl, V.; Kuchler, K.; Müller, M. et al.; Decker, T.; Ellmeier, W.: The Tyrosine Kinase Btk Regulates the Macrophage Response to Listeria monocytogenes Infection. PLoS One 8 (3), e60476 (2013)

Majer, O.; Bourgeois, C.; Zwolanek, F.; Lassnig, C.; Kerjaschki, D.; Mack, M.; ller, M. M.; Kuchler, K.: Type I Interferons Promote Fatal Immunopathology by Regulating Inflammatory Monocytes and Neutrophils during Candida Infections. PLoS Pathogens 8 (7), e1002811 (2012)

Zavrel, M.; Majer, O.; Kuchler, K.; Rupp, S.: Transcription Factor Efg1 Shows a Haploinsufficiency Phenotype in Modulating the Cell Wall Architecture and Immunogenicity of Candida albicans. Eukaryotic Cell 11 (2), pp. 129 - 140 (2012)

Seider, K.; Brunke, S.; Schild, L.; Jablonowski, N.; Wilson, D.; Majer, O.; Barz, D.; Haas, A.; Kuchler, K.; Schaller, M. et al.; Hube, B.: The Facultative Intracellular Pathogen Candida glabrata Subverts Macrophage Cytokine Production and Phagolysosome Maturation. The Journal of Immunology 187 (6), pp. 3072 - 3086 (2011)

Bourgeois, C.; Majer, O.; Frohner, I. E.; Lesiak-Markowicz, I.; Hildering, K.-S.; Glaser, W.; Stockinger, S.; Decker, T.; Akira, S.; Müller, M. et al.; Kuchler, K.: Conventional Dendritic Cells Mount a Type I IFN Response against Candida spp. Requiring Novel Phagosomal TLR7-Mediated IFN-β Signaling. The Journal of Immunology 186 (6), pp. 3104 - 3112 (2011)

Bourgeois, C.; Majer, O.; Frohner, I. E.; Tierney, L.; Kuchler, K.: Fungal attacks on mammalian hosts: pathogen elimination requires sensing and tasting. Current Opinion in Microbiology 13 (4), pp. 401 - 408 (2010)

Hnisz, D.; Majer, O.; Frohner, I. E.; Komnenovic, V.; Kuchler, K.: The Set3/Hos2 Histone Deacetylase Complex Attenuates cAMP/PKA Signaling to Regulate Morphogenesis and Virulence of Candida albicans. PLoS Pathogens 6 (5), e1000889 (2010)

Frohner, I. E.; Bourgeois, C.; Yatsyk, K.; Majer, O.; Kuchler, K.: Candida albicans cell surface superoxide dismutases degrade host‐derived reactive oxygen species to escape innate immune surveillance. Molecular Microbiology 71 (1), pp. 240 - 252 (2009)

Bourgeois, C.; Majer, O.; Frohner, I.; Kuchler, K.: In Vitro Systems for Studying the Interaction of Fungal Pathogens with Primary Cells from the Mammalian Innate Immune System. In: Host-Pathogen Interactions, pp. 125 - 139 (Eds. Rupp, S.; Sohn, K.). Humana Pr., Toronto, Heidelberg (2009)