Processing and signaling potential of extracellular RNAs transported inside and outside extracellular vesicles
- Date: Jun 20, 2022
- Time: 11:00 AM (Local Time Germany)
- Speaker: Juan Pablo Tosar
- Assistant Professor at the Faculty of Science, Universidad de la República (Uruguay) and Associated Researcher at the Pasteur Institute of Montevideo
- Location: Max Planck Institute for Infection Biology
- Host: Olivia Majer
- Contact: communication@mpiib-berlin.mpg.de
The seminar will be held on-site at the Max Planck Institute for Infection Biology and streamed via Zoom. If you would like to attend on-site or join the zoom meeting, please contact communication@mpiib-berlin.mpg.de to register.
RNAs encapsulated inside extracellular vesicles (EVs) can be transferred between mammalian cells and are also promising disease biomarkers in liquid biopsies. However, the majority of extracellular RNAs (exRNAs) in cell culture media and biofluids are not present inside EVs. We will discuss how abundant non-EV exRNAs are released from cells, are processed and shaped into smaller and highly resistant fragments by extracellular ribonucleases, and can be internalized and sensed by recipient immune and epithelial cells.