Publications of Thumbi Ndung'u

Muenchhoff, M.; Chung, A. W.; Roider, J.; Dugast, A.-S.; Richardson, S.; Kløverpris, H.; Leslie, A.; Ndung'u, T.; Moore, P.; Alter, G. et al.; Goulder, P. J. R.: Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection. mSphere 5 (6), e00880-20 (2020)

Naidoo, K. K.; Shangase, Z. B.; Rashid, T.; Ngubane, A.; Ismail, N.; Ndung'u, T.; Thobakgale, C. F.: The DARC-null trait is associated with moderate modulation of NK cell profiles and unaltered cytolytic T cell profiles in black South Africans. PLoS One 15 (11), e0242448 (2020)

Mann, J. K.; Ndung'u, T.: The potential of lactoferrin, ovotransferrinand lysozyme as antiviral andimmune-modulating agents in COVID-19. Future Virology 15 (9), pp. 609 - 624 (2020)

Attaf, M.; Roider, J.; Malik, A.; Rafael, C. R.; Dolton, G.; Predergast, A. J.; Leslie, A.; Ndung'u, T.; Kløverpris, H. N.; Sewell, A. K. et al.; Goulder, P. J.: Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life. FRONTIERS IN IMMUNOLOGY 11, 1587 (2020)

Singh, A.; Kazer, S. W.; Roider, J.; Krista, K. C.; Millar, J.; Asowata, O. E.; Ngoepe, A.; Ramsuran, D.; Fardoos, R.; Ardain, A. et al.; Muenchhoff, M.; Kuhn, W.; Karim, F.; Ndung'u, T.; Shalek, A. K.; Goulder, P.; Leslie, A.; Kløverpris, H. N.: Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy. Cell Reports 32 (11) (2020)

Jin, S. W.; Mwimanzi, F. M.; Mann, J. K.; Bwana, M. B.; Lee, G. Q.; Brumme, C. J.; Hunt, P. W.; Martin, J. N.; Bangsberg, D. R.; Ndung'u, T. et al.; Brumme, Z. L.; Brockman, M. A.: Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5. PLOS PATHOGENS 16 (9), 1008813 (2020)

Siedner, M. J.; Harling, G.; Derache, A.; Smit, T.; Khoza, T.; Gunda, R.; Mngomezulu, T.; Gareta, D.; Majozi, N.; Ehlers, E. et al.; Dreyer, J.; Nxumalo, S.; Dayi, N.; Ording-Jesperson, G.; Ngwenya, N.; Wong, E.; Iwuji, C.; Shahmanesh, M.; Seeley, J.; Oliveira, T. D.; Ndung'u, T.; Hanekom, W.; Herbst, K.: Protocol: Leveraging a demographic and health surveillance system for Covid-19 Surveillance in rural KwaZulu-Natal [version 2; peer review: 2 approved. Wellcome Open Research 5, 109 (2020)

Graham, S. M.; Agutu, C.; van der Elst, E.; Hassan, A. S.; Gichuru, E.; Mugo, P. M.; Farquhar, C.; Babigumira, J. B.; Goodreau, S. M.; Hamilton, D. T. et al.; Ndung'u, T.; Sirengo, M.; Chege, W.; Sanders, E. J.: A Novel HIV-1 RNA Testing Intervention to Detect Acute and Prevalent HIV Infection in Young Adults and Reduce HIV Transmission in Kenya: Protocol for a Randomized Controlled Trial. JMIR Research Protocols 9 (8), e16198 (2020)

Graham, S. M.; Agutu, C.; van der Elst, E.; Hassan, A. S.; Gichuru, E.; Mugo, P. M.; Farquhar, C.; Babigumira, J. B.; Goodreau, S. M.; Hamilton, D. T. et al.; Ndung'u, T.; Sirengo, M.; Chege, W.; Sanders, E. J.: A Novel HIV-1 RNA Testing Intervention to Detect Acute and Prevalent HIV Infection in Young Adults and Reduce HIV Transmission in Kenya: Protocol for a Randomized Controlled Trial. JMIR Research Protocols 9 (8), e16198 (2020)

Jennewein, M. F.; Mabuka, J.; Papia, C. L.; Boudreau, C. M.; Dong, K. L.; Ackerman, M. E.; Ndung'u, T.; Alter, G.: Tracking the Trajectory of Functional Humoral Immune Responses Following Acute HIV Infection. Frontiers in immunology 11, 1744 (2020)

Mann, J. K.; Rajkoomar, E.; Jin, S. W.; Mkhize, Q.; Baiyegunhi, O.; Mbona, P.; Brockman, M. A.; Ndung'u, T.: Consequences of HLA-associated mutations in HIV-1 subtype C Nef on HLA-I downregulation ability. Journal of medicial virology 92 (8), pp. 1182 - 1190 (2020)

Kasprowicz, V. O.; Chopera, D.; Waddilove, K. D.; Brockman, M. A.; Gilmour, J.; Hunter, E.; Kilembe, W.; Karita, E.; Gaseitsiwe, S.; Sanders, E. J. et al.; Ndung'u, T.: African-led health research and capacity building- is it working? BMC Public Health 20 (1), 1104 (2020)

Ndlovu, B.; Gounder, K.; Muema, D.; Raju, N.; Hermanus, T.; Mthethwa, Q.; Robertson, K.; Walker, B. D.; Georgiev, I. S.; Morris, L. et al.; Moore, P. L.; Ndung'u, T.: Envelope characteristics in individuals who developed neutralizing antibodies targeting different epitopes in HIV-1 subtype C infection. Virology 546, pp. 1 - 12 (2020)

Umviligihozo, G.; Cobarrubias, K. D.; Chandrarathna, S.; Jin, S. W.; Reddy, N.; Byakwaga, H.; Muzoora, C.; Bwana, M. B.; Lee, G. Q.; Hunt, P. W. et al.; Martin, J. N.; Brumme, C. J.; Bangsberg, D. R.; Karita, E.; Allen, S.; Hunter, E.; Ndung'u, T.; Brumme, Z. L.; Brockman, M. A.: Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes. Journal of Virology 94 (14), e00293-20 (2020)

Muema, D. M.; Mthembu, M.; Schiff, A. E.; Singh, U.; Corleis, B.; Chen, D.; Bassett, T.; Rasehlo, S. S.; Nyamande, K.; Khan, D. F. et al.; Maharaj, P.; Mitha, M.; Suleman, M.; Mhlane, Z.; Naidoo, T.; Ramjit, D.; Karim, F.; Kwon, D. S.; Ndung'u, T.; Wong, E. B.: Contrasting Inflammatory Signatures in Peripheral Blood and Bronchoalveolar Cells Reveal Compartment-Specific Effects of HIV Infection. Frontiers in immunology 11, 864 (2020)

Chitneni, P.; Beksinska, M.; Dietrich, J. J.; Jaggernath, M.; Closson, K.; Smith, P.; Lewis, D. A.; Matthews, L. T.; Smit, J.; Ndung'u, T. et al.; Brockman, M.; Gray, G.; Kaida, A.: Partner notification and treatment outcomes among South African adolescents and young adults diagnosed with a sexually transmitted infection via laboratory-based screening. International Journal of STD and AIDS 31 (7), pp. 627 - 636 (2020)

Millar, J. R.; Bengu, N.; Fillis, R.; Sprenger, K.; Ntlantsana, V.; Vieira, V. A.; Khambati, N.; Archary, M.; Muenchhoff, M.; Groll, A. et al.; Grayson, N.; Adamson, J.; Govender, K.; Dong, K.; Kiepiela, P.; Walker, B. D.; Bonsall, D.; Connor, T.; Bull, M. J.; Nxele, N.; Roider, J.; Ismail, N.; Adland, E.; Puertas, M. C.; Martinez-Picado, J.; Matthews, P. C.; Ndung'u, T.; Goulder, P.: HIGH- FREQUENCY failure of combination antiretroviral therapy in paediatric HIV infection is associated with unmet maternal needs causing maternal NON-ADHERENCE. EClinicalMedicine 22, 100344 (2020)

Muema, D. M.; Akilimali, N. A.; Ndumnego, O. C.; Rasehlo, S. S.; Durgiah, R.; Ojwach, D. B.A.; Ismail, N.; Dong, M.; Moodley, A.; Dong, K. L. et al.; Ndhlovu, Z. M.; Mabuka, J. M.; Walker, B. D.; Mann, J. K.; Ndung'u, T.: Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection. BMC Medicine 18 (1), 81 (2020)

Kazer, S. W.; Aicher, T. P.; Muema, D. M.; Carroll, S. L.; Ordovas-Montanes, J.; Miao, V. N.; Tu, A. A.; Ziegler, C. G. K.; Nyquist, S. K.; Wong, E. B. et al.; Ismail, N.; Dong, M.; Moodley, A.; Berger, B.; Love, J. C.; Dong, K. L.; Leslie, A.; Ndhlovu, Z. M.; Ndung'u, T.; Walker, B. D.; Shalek, A. K.: Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection. Nature Medicine 26 (4), pp. 511 - 518 (2020)

Elliott, T.; Sanders, E. J.; Doherty, M.; Ndung'u, T.; Cohen, M.; Patel, P.; Cairns, G.; Rutstein, S. E.; Ananworanich, J.; Brown, C. et al.; Fidler, S.: Challenges of HIV diagnosis and management in the context of pre‐exposure prophylaxis (PrEP), post‐exposure prophylaxis (PEP), test and start and acute HIV infection: a scoping review. Journal of the International AIDS Society 22 (12), e25419 (2019)