Publications of Thumbi Ndung'u

Liu, Y.; Ndumnego, O. C.; Chen, T.; Kim, R. S.; Jenny-Avital, E. R.; Ndung'u, T.; Wilson, D.; Achkar, J. M.: Soluble CD14 as a Diagnostic Biomarker for Smear-Negative HIV-Associated Tuberculosis. Pathogens 7 (1), E26 (2018)

Seipone, I. D.; Singh, R.; Patel, V. B.; Singh, A.; Gordon, M. L.; Muema, D. M.; Dheda, K.; Ndung'u, T.: Tuberculous meningitis is associated with higher cerebrospinal HIV-1 viral loads compared to other HIV-1-associated meningitides. PLoS One 13 (2), e0192060 (2018)

Ramsuran, V.; Naranbhai, V.; Horowitz, A.; Qi, Y.; Martin, M. P.; Yuki, Y.; Gao, X.; Walker-Sperling, V.; Prete, G. Q. D.; Schneider, D. K. et al.; Lifson, J. D.; Fellay, J.; Deeks, S. G.; Martin, J. N.; Goedert, J. J.; Wolinsky, S. M.; Michael, N. L.; Kirk, G. D.; Buchbinder, S.; Haas, D.; Ndung'u, T.; Goulder, P.; Parham, P.; Walker, B. D.; Carlson, J. M.; Carrington, M.: Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells. Science 359 (6371), pp. 86 - 90 (2018)

Dong, K. L.; Moodley, A.; Kwon, D. S.; Ghebremichael, M. S.; Dong, M.; Ismail, N.; Ndhlovu, Z. M.; Mabuka, J. M.; Muema, D. M.; Pretorius, K. et al.; Lin, N.; Walker, B. D.; Ndung'u, T.: Detection and treatment of Fiebig stage I HIV-1 infection in young at-risk women in South Africa: a prospective cohort study. Lancet HIV 5 (1), pp. e35 - e44 (2018)

Muenchhoff, M.; Healy, M.; Singh, R.; Roider, J.; Groll, A.; Kindra, C.; Sibaya, T.; Moonsamy, A.; McGregor, C.; Phan, M. Q. et al.; Palma, A.; Kloverpris, H.; Leslie, A.; Bobat, R.; LaRussa, P.; Ndung'u, T.; Goulder, P.; Sobieszczyk, M. E.; Archary, M.: Malnutrition in HIV-Infected Children Is an Indicator of Severe Disease with an Impaired Response to Antiretroviral Therapy. AIDS Research and Human Retroviruses 43 (1), pp. 46 - 55 (2018)

Mwimanzi, F.; Toyoda, M.; Mahiti, M.; Mann, J. K.; Martin, J. N.; Bangsberg, D.; Brockman, M. A.; Goulder, P.; Kirchhoff, F.; Brumme, Z. L. et al.; Ndung'u, T.; Uenoa, T.: Resistance of Major Histocompatibility Complex Class B (MHC-B) to Nef-Mediated Downregulation Relative to that of MHC-A Is Conserved among Primate Lentiviruses and Influences Antiviral T Cell Responses in HIV-1-Infected Individuals. Journal of Virology 92 (1), e01409-17 (2018)

Zulu, M. Z.; Naidoo, K. K.; Mncube, Z.; Jaggernath, M.; Goulder, P. J.R.; Ndung'u, T.; Altfeld, M.; Thobakgale, C. F.: Reduced Expression of Siglec-7, NKG2A, and CD57 on Terminally Differentiated CD56−CD16+ Natural Killer Cell Subset Is Associated with Natural Killer Cell Dysfunction in Chronic HIV-1 Clade C Infection. AIDS Research and Human Retroviruses 33 (12), pp. 1205 - 1213 (2017)

Ngcapu, S.; Theys, K.; Libin, P.; Marconi, V. C.; Sunpath, H.; Ndung'u, T.; Gordon, M. L.: Characterization of Nucleoside Reverse Transcriptase Inhibitor-Associated Mutations in the RNase H Region of HIV-1 Subtype C Infected Individuals. Viruses 9 (11), 330 (2017)

Akilimali, N. A.; Chang, C. C.; Muema, D. M.; Reddy, T.; Moosa, M.-Y. S.; Lewin, S. R.; French, M. A.; Ndung'u, T.: Plasma But Not Cerebrospinal Fluid Interleukin 7 and Interleukin 5 Levels Pre–Antiretroviral Therapy Commencement Predict Cryptococcosis-Associated Immune Reconstitution Inflammatory Syndrome. Clinical Infectious Diseases 65 (9), pp. 1551 - 1559 (2017)

Bhattacharya, D.; Danaviah, S.; Muema, D. M.; Akilimali, N. A.; Moodley, P.; Ndung'u, T.; Das, G.: Cellular Architecture of Spinal Granulomas and the Immunological Response in Tuberculosis Patients Coinfected with HIV. Frontiers in immunology 8, 1120 (2017)

Mabuka, J. M.; Dugast, A.-S.; Muema, D. M.; Reddy, i.; Ramlakhan, Y.; Euler, Z.; Ismail, N.; Moodley, A.; Dong, K. L.; Morris, L. et al.; Walker, B. D.; Alter, G.; Ndung'u, T.: Plasma CXCL13 but Not B Cell Frequencies in Acute HIV Infection Predicts Emergence of Cross-Neutralizing Antibodies. Frontiers in immunology 8, 1104 (2017)

Naidoo, V. L.; Mann, J. K.; Noble, C.; Adland, E.; Carlson, J. M.; Thomas, J.; Brumme, C. J.; Thobakgale-Tshabalala, C. F.; Brumme, Z. L.; Brockman, M. A. et al.; Goulder, P. J. R.; Ndung'u, T.: Mother-to-Child HIV Transmission Bottleneck Selects for Consensus Virus with Lower Gag-Protease-Driven Replication Capacity. Journal of Virology 91 (17), e00518-17 (2017)

Kiguoya, M. W.; Mann, J. K.; Chopera, D.; Gounder, K.; Lee, G. Q.; Hunt, P. W.; Martin, J. N.; Ball, T. B.; Kimani, J.; Brumme, Z. L. et al.; Brockman, M. A.; Ndung'u, T.: Subtype-Specific Differences in Gag- Protease-Driven Replication Capacity Are Consistent with Intersubtype Differences in HIV-1 Disease Progression. Journal of Virology 91 (13), e00253-17 (2017)

Lee, G. Q.; Orlova-Fink, N.; Einkauf, K.; Chowdhury, F. Z.; Sun, X.; Harrington, S.; Kuo, H.-H.; Hua, S.; Chen, H.-R.; Ouyang, Z. et al.; Reddy, K.; Dong, K.; Ndung'u, T.; Walker, B. D.; Rosenberg, E. S.; Yu, X. G.; Lichterfeld, M.: Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells. Journal of Clinical Investigation 127 (7), pp. 2689 - 2696 (2017)

Gounder, K.; Oyaro, M.; Padayachi, N.; Zulu, T. M.; de Oliveira, T.; Wylie, J.; Ndung'u, T.: Complex Subtype Diversity of HIV-1 Among Drug Users in Major Kenyan Cities. AIDS Research and Human Retroviruses 33 (5), pp. 500 - 510 (2017)

Laher, F.; Ranasinghe, S.; Porichis, F.; Mewalal, N.; Pretorius, K.; Ismail, N.; Buus, S.; Stryhn, A.; Carrington, M.; Walker, B. D. et al.; Ndung'u, T.; Ndhlovu, Z. M.: HIV Controllers Exhibit Enhanced Frequencies of Major Histocompatibility Complex Class II Tetramer+ Gag-Specific CD4+ T Cells in Chronic Clade C HIV-1 Infection. Journal of Virology 91 (7), e02477-16 (2017)

Chang, C. C.; Kangethe, R.; Omarjee, S.; Hiramen, K.; Gosnell, B.; Sojane, K.; Moosa, M.-Y. S.; Lewin, S. R.; French, M. A.; Ndung'u, T.: Relationship of Human Immunodeficiency Virus Viral Load in Cerebrospinal Fluid and Plasma in Patients Co-infected With Cryptococcal Meningitis. Open Forum Infectious Diseases 4 (2), ofx032 (2017)

Thobakgale, C.; Naidoo, K.; McKinnon, L. R.; Werner, L.; Samsunder, N.; Karim, S. A.; Ndung'u, T.; Altfeld, M.; Naidoo, K.: Interleukin 1-Beta (IL-1) Production by Innate Cells Following TLR Stimulation Correlates With TB Recurrence in ART-Treated HIV-Infected Patients. Journal of Acquired Immune Deficiency Syndromes 74 (2), pp. 213 - 220 (2017)

Wong, E. B.; Ndung'u, T.; Kasprowicz, V. O.: The role of mucosal-associated invariant T cells in infectious diseases. Immunology 150 (1), pp. 45 - 54 (2017)

Muenchhoff, M.; Adland, E.; Karimanzira, O.; Crowther, C.; Pace, M.; Csala, A.; Leitman, E.; Moonsamy, A.; McGregor, C.; Hurst, J. et al.; Groll, A.; Mori, M.; Sinmyee, S.; Thobakgale, C.; Tudor-Williams, G.; Prendergast, A. J.; Kloverpris, H.; Roider, J.; Leslie, A.; Shingadia, D.; Brits, T.; Daniels, S.; Frater, J.; Willberg, C. B.; Walker, B. D.; Ndung'u, T.; Jooste, P.; Moore, P. L.; Morris, L.; Goulder, P.: Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection. Science Translational Medicine 8 (358), 358ra125 (2016)