Publications of Thumbi Ndung'u

Zhu, M.; Frank, M. W.; Radka, C. D.; Jeanfavre, S.; Xu, J.; Tse, M. W.; Pacheco, J. A.; Kim, J. S.; Pierce, K.; Deik, A. et al.; Hussain, F. A.; Elsherbini, J.; Hussain, S.; Xulu, N.; Khan, N.; Pillay, V.; Mitchell, C. M.; Dong, K. L.; Ndung'u, T.; Clish, C. B.; Rock, C. O.; Blainey, P. C.; Bloom, S. M.; Kwon, D. S.: Vaginal Lactobacillus fatty acid response mechanisms reveal a metabolite-targeted strategy for bacterial vaginosis treatment. Cell 187 (19), e29, pp. 5413 - 5430 (2024)

Sonela, N.; Mann, J.; Godwe, C.; Goni, O. H.; Tchakoute, M.; Nkoue, N.; de Oliveira, T.; Brockman, M. A.; Brumme, Z. L.; Ndung'u, T. et al.; Tongo, M.: No detectable differences in Nef-mediated downregulation of HLA-I and CD4 molecules among HIV-1 group M lineages circulating in Cameroon, where the pandemic originated. Front Virol 4 (2024)

Krause, R.; Snyman, J.; Shi-Hsia, H.; Muema, D.; Karim, F.; Ganga, Y.; Ngoepe, A.; Zungu, Y.; Gazy, I.; Bernstein, M. et al.; Khan, K.; Mazibuko, M.; Mthabela, N.; Ramjit, D.; COMMIT-KZN Team; Limbo, O.; Jardine, J.; Sok, D.; Wilson, I. A.; Hanekom, W.; Sigal, A.; Kløverpris, H.; Ndung'u, T.; Leslie, A.: HIV skews the SARS-CoV-2 B cell response towards an extrafollicular maturation pathway. eLife, e79924 (2022)

Snyman, J.; Hwa, S. H.; Krause, R.; Muema, D.; Reddy, T.; Ganga, Y.; Karim, F.; Leslie, A.; Sigal, A.; Ndung'u, T. et al.; COMMIT-KZN Team: Similar Antibody Responses Against Severe Acute Respiratory Syndrome Coronavirus 2 in Individuals Living Without and With Human Immunodeficiency Virus on Antiretroviral Therapy During the First South African Infection Wave. Clinical Infectious Diseases 75 (1) (2022)

Baiyegunhi, O. O.; Mann, J.; Khaba, T.; Nkosi, T.; Mbatha, A.; Ogunshola, F.; Chasara, C.; Ismail, N.; Ngubane, T.; Jajbhay, I. et al.; Pansegrouw, J.; Dong, K. L.; Walker, B. D.; Ndung'u, T.; Ndhlovu, Z. M.: CD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection. Nature Communications 13 (1) (2022)

Bengu, N.; Mchunu, N.; Mokhethi, S.; Fillis, R.; Cromhout, G.; van Lobenstein, J.; Graza, Y.; Kapongo, C.; Chinniah, K.; Bhoola, R. et al.; Adland, E.; Puertas, M. C.; Ndung'u, T.; Martinez-Picado, J.; Archary, M.; Goulder, P. J. R.: Next-generation point-of-care testing in pediatric human immunodeficiency virus infection facilitates diagnosis and monitoring of treatment. MEDICINE 101 (27), e29228 (2022)

Ogunshola, F. J.; Smidt, W.; Naidoo, A. F.; Nkosi, T.; Ngubane, T.; Khaba, T.; Baiyegunhi, O. O.; Mahlobo, B.; Rasehlo, S.; Ngema, N. et al.; Jajbhay, I.; Dong, K. L.; Ramsuran, V.; Pansegrouw, J.; Ndung'u, T.; Walker, B. D.; de Oliveria, T.; Ndhlovu, Z. M.: Hypermethylation at the CXCR5 gene locus limits trafficking potential of CD81 T cells into B-cell follicles during HIV-1 infection. Blood Adv 6 (6), pp. 1904 - 1916 (2022)

Ogunshola, F. J.; Smidt, W.; Naidoo, A. F.; Nkosi, T.; Ngubane, T.; Khaba, T.; Baiyegunhi, O. O.; Mahlobo, B.; Rasehlo, S.; Ngema, N. et al.; Jajbhay, I.; Dong, K. L.; Ramsuran, V.; Pansegrouw, J.; Ndung'u, T.; Walker, B. D.; de Oliveria, T.; Ndhlovu, Z. M.: Hypermethylation at the CXCR5 gene locus limits trafficking potential of CD8+ T cells into B-cell follicles during HIV-1 infection. Blood Advances 6 (6) (2022)

Bloom, S. M.; Mafunda, N. A.; Woolston, B. M.; Hayward, M. R.; Frempong, J. F.; Abai, A. B.; Xu, J.; Mitchell, A. J.; Westergaard, X.; Hussain, F. A. et al.; Xulu, N.; Dong, M.; Dong, K. L.; Gumbi, T.; Ceasar, F. X.; Rice, J. K.; Choksi, N.; Ismail, N.; Ndung'u, T.; Ghebremichael, M. S.; Relman, D. A.; Balskus, E. P.; Mitchell, C. M.; Kwon, D. S.: Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation. Nature Microbiology 7, pp. 434 - 450 (2022)

Singer, S. N.; Ndumnego, O. C.; Kim, R. S.; Ndung'u, T.; Anastos, K.; French, A.; Churchyard, G.; Paramithiothis, E.; Kasprowicz, V. O.; Achkar, J. M.: Plasma host protein biomarkers correlating with increasing Mycobacterium tuberculosis infection activity prior to tuberculosis diagnosis in people living with HIV. EBioMedicine 75, 103787 (2021)

Olivier, S.; Murray, T.; Matthews, P.; Mhlongo, N.; Gunda, R.; Baisley, K.; Gareta, D.; Modise, T.; Smit, T.; Herbst, K. et al.; Mpofana, X.; Ndung'u, T.; Koole, O.; Pillay, D.; Hanekom, W.; Wong, E.; Siedner, M. J.; team, V. S.: Pitfalls of Single Measurement Screening for Diabetes and Hypertension in Community-Based Settings. Glob Heart 16 (1) (2021)

Millar, J. R.; Bengu, N.; Vieira, V. A.; Adland, E.; Roider, J.; Muenchhoff, M.; Fillis, R.; Sprenger, K.; Ntlantsana, V.; Fatti, I. et al.; Archary, M.; Groll, A.; Ismail, N.; García-Guerrero, M. C.; Matthews, P. C.; Ndung'u, T.; Puertas, M. C.; Martinez-Picado, J.; Goulder, P.: Early Initiation of Antiretroviral Therapy Following In Utero HIV Infection Is Associated With Low Viral Reservoirs but Other Factors Determine Viral Rebound. J Infect Dis 224 (11), pp. 1925 - 1934 (2021)

Gunda, R.; Koole, O.; Gareta, D.; Olivier, S.; Surujdeen, A.; Smit, T.; Modise, T.; Dreyer, J.; Ording-Jespersen, G.; Munatsi, D. et al.; Nxumalo, S.; Khoza, T.; Mhlongo, N.; Baisley, K.; Seeley, J.; Grant, A. D.; Herbst, K.; Ndung'u, T.; Hanekom, W. A.; Siedner, M. J.; Pillay, D.; Wong, E. B.; Vukuzazi Study Team: Cohort Profile: The Vukuzazi ('Wake Up and Know Yourself' in isiZulu) population science programme. International Journal of Epidemiology (2021)

Asowata, O. E.; Singh, A.; Ngoepe, A.; Herbert, N.; Fardoos, R.; Reddy, K.; Zungu, Y.; Nene, F.; Mthabela, N.; Ramjit, D. et al.; Karim, F.; Govender, K.; Ndung'u, T.; Porterfield, J. Z.; Adamson, J. H.; Madela, F. G.; Manzini, V. T.; Anderson, F.; Leslie, A.; Kløverpris, H. N.: Irreversible depletion of intestinal CD4+ T cells is associated with T cell activation during chronic HIV infection. JCI Insight. 6 (22), e146162 (2021)

Vieira, V. A.; Adland, E.; Malone, D. F. G.; Martin, M. P.; Groll, A.; Ansari, M. A.; Garcia-Guerrero, M. C.; Puertas, M. C.; Muenchhoff, M.; Guash, C. F. et al.; Brander, C.; Martinez-Picado, J.; Bamford, A.; Tudor-Williams, G.; Ndung'u, T.; Walker, B. D.; Ramsuran, V.; Frater, J.; Jooste, P.; Peppa, D.; Carrington, M.; Goulder, P. J. R.: An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults. PLoS Pathogens 17 (11), e1010090 (2021)

Nduati, E. W.; Gorman, M. J.; Sein, Y.; Hermanus, T.; Yuan, D.; Oyaro, I.; Muema, D. M.; Ndung'u, T.; Alter, G.; Moore, P. L.: Coordinated Fc-effector and neutralization functions in HIV-infected children define a window of opportunity for HIV vaccination. AIDS 35 (12) (2021)

Naidoo, K. K.; Ndumnego, O. C.; Ismail, N.; Dong, K. L.; Ndung'u, T.: Antigen Presenting Cells Contribute to Persistent Immune Activation Despite Antiretroviral Therapy Initiation During Hyperacute HIV-1 Infection. Frontiers in immunology 12, 738743 (2021)

Byrne, E. H.; Farcasanu, M.; Bloom, S. M.; Xulu, N.; Xu, J.; Jr, B. L. H.; Mafunda, N. A.; Hayward, M. R.; Dong, M.; Dong, K. L. et al.; Gumbi, T.; Ceasar, F. X.; Ismail, N.; Ndung'u, T.; Gosmann, C.; Ghebremichael, M. S.; Handley, S. A.; Mitchell, C. M.; Villani, A.-C.; Kwon, D. S.: Antigen Presenting Cells Link theFemale Genital Tract Microbiometo Mucosal Inflammation, WithHormonal Contraception as anAdditional Modulator ofInflammatory Signatures. Frontiers in Cellular and Infection Microbiology 11, 733619 (2021)

Hassan, A. S.; Hare, J.; Gounder, K.; Nazziwa, J.; Karlson, S.; Olsson, L.; Streatfield, C.; Kamali, A.; Karita, E.; Kilembe, W. et al.; Price, M. A.; Borrow, P.; Björkman, P.; Kaleebu, P.; Allen, S.; Hunter, E.; Ndung'u, T.; Gilmour, J.; Rowland-Jones, S.; Esbjörnsson, J.; Sanders, E. J.: A Stronger Innate Immune Response During Hyperacute Human Immunodeficiency Virus Type 1 (HIV-1) Infection Is Associated With Acute Retroviral Syndrome. Clin Infect Dis 73 (5), pp. 832 - 841 (2021)

Snyman, J.; Hwa, S.-H.; Krause, R.; Muema, D.; Reddy, T.; Ganga, Y.; Karim, F.; Leslie, A.; Sigal, A.; Ndung'u, T. et al.; Team, C.-K.: Similar antibody responses against SARS-CoV-2 in HIV uninfected and infected individuals on antiretroviral therapy during the first South African infection wave. Clinical Infectious Diseases, ciab758 (2021)