Publications of Alex Sigal

Journal Article (37)

2022
Journal Article
Snyman, J.; Hwa, S. H.; Krause, R.; Muema, D.; Reddy, T.; Ganga, Y.; Karim, F.; Leslie, A.; Sigal, A.; Ndung'u, T. et al.; COMMIT-KZN Team: Similar Antibody Responses Against Severe Acute Respiratory Syndrome Coronavirus 2 in Individuals Living Without and With Human Immunodeficiency Virus on Antiretroviral Therapy During the First South African Infection Wave. Clinical Infectious Diseases 75 (1) (2022)
Journal Article
Hwa, h.-H.; Snyman, J.; Bernstein, M.; Ganga, Y.; Cele, S.; Muema, D.; Tan, C. W.; Khan, K.; Karim, F.; Hanekom, W. et al.; Bernstein, L.; Kaufmann, S. H. E.; Wang, L.-F.; Ndung’u, T.; Sigal, A.; COMMIT-KZN Team: Association Between Human Immunodeficiency Virus Viremia and compromised Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Beta Variant. The Journal of Infectious Diseases (2022)
Journal Article
Hwa, S.-H.; Snyman, J.; Bernstein, M.; Ganga, Y.; Cele, S.; Muema, D.; Tan, C. W.; Khan, K.; Karim, F.; Hanekom, W. et al.; Bernstein, L.; Kaufmann, S. H. E.; Wang, L.-F.; Ndung'u, T.; Sigal, A.: HIV viremia is associated with compromised SARS-CoV-2 Beta variant neutralization. The Journal of Infectious Diseases (2022)
Journal Article
Khan, K.; Karim, F.; Ganga, Y.; Bernstein, M.; Jule, Z.; Reedoy, K.; Cele, S.; Lustig, G.; Amoako, D.; Wolter, N. et al.; Samsunder, N.; Sivro, A.; San, J. E.; Giandhari, J.; Tegally, H.; Pillay, S.; Naidoo, Y.; Mazibuko, M.; Miya, Y.; Ngcobo, N.; Manickchund, N.; Magula, N.; Karim, Q. A.; von Gottberg, A.; Karim, S. S. A.; Hanekom, W.; Gosnell, B. I.; Team, C.-K.; Lessells, R. J.; de Oliveira, T.; Moosa, M.-Y. S.; Sigal, A.: Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection. Nature Communications 13 (1), 4686 (2022)
Journal Article
Greaney, A. J.; Eguia, R. T.; Starr, T. N.; Khan, K.; Franko, N.; Logue, J. K.; Lord, S. M.; Speake, C.; Chu, H. Y.; Sigal, A. et al.; Bloom, J. D.: The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes. PLoS Pathogens 18 (6), e1010592 (2022)
Journal Article
Khan, K.; Karim, F.; Cele, S.; Reedoy, K.; San, J. E.; Lustig, G.; Tegally, H.; Rosenberg, Y.; Bernstein, M.; Jule, Z. et al.; Ganga, Y.; Ngcobo, N.; Mazibuko, M.; Mthabela, N.; Mhlane, Z.; Mbatha, N.; Miya, Y.; Giandhari, J.; Ramphal, Y.; Naidoo, T.; Sivro, A.; Samsunder, N.; Kharsany, A. B. M.; Amoako, D.; Bhiman, J. N.; Manickchund, N.; Karim, Q. A.; Magula, N.; Karim, S. S. A.; Gray, G.; Hanekom, W.; von Gottberg, A.; Team, C.-K.; Milo, R.; Gosnell, B. I.; Lessells, R. J.; Moore, P. L.; de Olveira, T.; Moosa, M.-Y. S.; Sigal, A.: Omicron infection enhances Delta antibody immunity in vaccinated persons. Nature (2022)
Journal Article
Sigal, A.; Milo, R.; Jassat, W.: Estimating disease severity of Omicron and Delta SARS-CoV-2 infections COMMENT. Nature Reviews Immunology 22 (5), pp. 267 - 269 (2022)
Journal Article
Reuschl, A.-K.; Mesner, D.; Shivkumar, M.; Whelan, M. V. X.; Pallett, L. J.; Guerra-Assunção, J. A.; Madansein, R.; Dullabh, K. J.; Sigal, A.; Thornhill, J. P. et al.; Herrera, C.; Fidler, S.; Noursadeghi, M.; Maini, M. K.; Jolly, C.: HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells. Cell Reports 39 (2), 110650 (2022)
Journal Article
Scheepers, C.; Everatt, J.; Amoako, D. G.; Tegally, H.; Wibmer, C. K.; Mnguni, A.; Ismail, A.; Mahlangu, B.; Lambson, B. E.; Martin, D. P. et al.; Wilkinson, E.; San, J. E.; Giandhari, J.; Manamela, N.; Ntuli, N.; Kgagudi, P.; Cele, S.; Richardson, S. I.; Pillay, S.; Mohale, T.; Ramphal, U.; Naidoo, Y.; Khumalo, Z. T.; Kwatra, G.; Gray, G.; Bekker, L.-G.; Madhi, S. A.; Baillie, V.; Voorhis, W. C. V.; Treurnicht, F. K.; Venter, M.; Mlisana, K.; Wolter, N.; Sigal, A.; Williamson, C.; Hsiao, N.-Y.; Msomi, N.; Maponga, T.; Preiser, W.; Makatini, Z.; Lessells, R.; Moore, P. L.; de Oliveira, T.; von Gottberg, A.; Bhiman, J. N.: Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage. Nature Communications 13 (1), 1976 (2022)
Journal Article
Sigal, A.; Milo, R.; Jassat, W.: Estimating disease severity of Omicron and Delta SARS-CoV-2 infections. Nature Reviews Immunology 22, pp. 267 - 269 (2022)
Journal Article
Cele, S.; Jackson, L.; Khoury, D. S.; Khan, K.; Moyo-Gwete, T.; Tegally, H.; San, J. E.; Cromer, D.; Scheepers, C.; Amoako, D. G. et al.; Karim, F.; Bernstein, M.; Lustig, G.; Archary, D.; Smith, M.; Ganga, Y.; Jule, Z.; Reedoy, K.; Hwa, S.-H.; Giandhari, J.; Blackburn, J. M.; Gosnell, B. I.; Karim, S. S. A.; Hanekom, W.; NGS-SA, COMMIT-KZN Team; von Gottberg, A.; Bhiman, J. N.; Lessells, R. J.; Moosa, M.-Y. S.; Davenport, M. P.; de Oliveira, T.; Moore, P. L.; Sigal, A.: Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization. Nature 602, pp. 654 - 656 (2022)
Journal Article
Cele, S.; Karim, F.; Lustig, G.; San, J. E.; Hermanus, T.; Tegally, H.; Snyman, J.; Moyo-Gwete, T.; Wilkinson, E.; Bernstein, M. et al.; Khan, K.; Hwa, S.-H.; Tilles, S. W.; Singh, L.; Giandhari, J.; Mthabela, N.; Mazibuko, M.; Ganga, Y.; Gosnell, B. I.; Karim, S. S. A.; Hanekom, W.; Voorhis, W. C. V.; Ndung'u, T.; Team, C.-K.; Lessells, R. J.; Moore, P. L.; Moosa, M.-Y. S.; de Oliveira, T.; Sigal, A.: SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape. Cell Host & Microbe 30 (2) (2022)
Journal Article
Meng, B.; Abdullahi, A.; Ferreira, I. A. T. M.; Goonawardane, N.; Saito, A.; Kimura, I.; Yamasoba, D.; Gerber, P. P.; Fatihi, S.; Rathore, S. et al.; Zepeda, S. K.; Papa, G.; Kemp, S. A.; Ikeda, T.; Toyoda, M.; Tan, T. S.; Kuramochi, J.; Mitsunaga, S.; Ueno, T.; Shirakawa, K.; Takaori-Kondo, A.; Brevini, T.; Mallery, D. L.; Charles, O. J.; Collaboration, C.-N. B. C.-; Japan, G. t. P.; Consortium, E.-C.; Bowen, J. E.; Joshi, A.; Walls, A. C.; Jackson, L.; Martin, D.; Smith, K. G. C.; Bradley, J.; Briggs, J. A. G.; Choi, J.; Madissoon, E.; Meyer, K.; Mlcochova, P.; Ceron-Gutierrez, L.; Doffinger, R.; Teichmann, S. A.; Fisher, A. J.; Pizzuto, M. S.; de Marco, A.; Corti, D.; Hosmillo, M.; Lee, J. H.; James, L. C.; Thukral, L.; Veesler, D.; Sigal, A.; Sampaziotis, F.; Goodfellow, I. G.; Matheson, N. J.; Sato, K.; Gupta, R. K.: Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity. Nature 603 (7902), pp. 706 - 714 (2022)
Journal Article
Keeton, R.; Tincho, M. B.; Ngomti, A.; Baguma, R.; Benede, N.; Suzuki, A.; Khan, K.; Cele, S.; Bernstein, M.; Karim, F. et al.; Madzorera, S. V.; Moyo-Gwete, T.; Mennen, M.; Skelem, S.; Adriaanse, M.; Mutithu, D.; Aremu, O.; Stek, C.; du Bruyn, E.; Mescht, M. A. V. D.; de Beer, Z.; de Villiers, T. R.; Bodenstein, A.; van den Berg, G.; Mendes, A.; Strydom, A.; Venter, M.; Giandhari, J.; Naidoo, Y.; Pillay, S.; Tegally, H.; Grifoni, A.; Weiskopf, D.; Sette, A.; Wilkinson, R. J.; de Oliveira, T.; Bekker, L.-G.; Gray, G.; Ueckermann, V.; Rossouw, T.; Boswell, M. T.; Bihman, J.; Moore, P. L.; Sigal, A.; Ntusi, N. A. B.; Burgers, W. A.; Riou, C.: T cell responses to SARS-CoV-2 spike cross-recognize Omicron. Nature 603, pp. 488 - 492 (2022)
Journal Article
Sigal, A.: Milder disease with Omicron: is it the virus or the pre-existing immunity? Nature Reviews Immunology (2022)
2021
Journal Article
Rodel, H. E.; Ferreira, I. A. T. M.; Ziegler, C. G. K.; Ganga, Y.; Bernstein, M.; Hwa, S.-H.; Nargan, K.; Lustig, G.; Kaplan, G.; Noursadeghi, M. et al.; Shalek, A. K.; Steyn, A. J. C.; Sigal, A.: Aggregated Mycobacterium tuberculosis Enhances the Inflammatory Response. Frontiers in Microbiology 12, 757134 (2021)
Journal Article
Kolloli, A.; Kumar, R.; Singh, P.; Narang, A.; Kaplan, G.; Sigal, A.; Subbian, S.: Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology. Commun Biol. 4 (1) (2021)
Journal Article
Karim, F.; Gazy, I.; Cele, S.; Zungu, Y.; Krause, R.; Bernstein, M.; Khan, K.; Ganga, Y.; Rodel, H.; Mthabela, N. et al.; Mazibuko, M.; Muema, D.; Ramjit, D.; Ndung'u, T.; Hanekom, W.; Gosnell, B.; COMMIT-KZN Team; Lessells, R. J.; Wong, E. B.; de Oliveira, T.; Moosa, M.-Y. S.; Lustig, G.; Leslie, A.; Kløverpris, H.; Sigal, A.: HIV status alters disease severity and immune cell responses in Beta variant SARS-CoV-2 infection wave. eLife 10, e67397 (2021)
Journal Article
Lustig, G.; Cele, S.; Karim, F.; Derache, A.; Ngoepe, A.; Khan, K.; Gosnell, B. I.; Moosa, M.-Y. S.; Ntshuba, N.; Marais, S. et al.; Jeena, P. M.; Govender, K.; Adamson, J.; Kløverpris, H.; Gupta, R. K.; Harrichandparsad, R.; Patel, V. B.; Sigal, A.: T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy. PLoS Pathogens 9, e1009871 (2021)
Journal Article
Snyman, J.; Hwa, S.-H.; Krause, R.; Muema, D.; Reddy, T.; Ganga, Y.; Karim, F.; Leslie, A.; Sigal, A.; Ndung'u, T. et al.; Team, C.-K.: Similar antibody responses against SARS-CoV-2 in HIV uninfected and infected individuals on antiretroviral therapy during the first South African infection wave. Clinical Infectious Diseases, ciab758 (2021)
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