Publications of A. Sigal

Journal Article (43)

2024
Journal Article
Jaumdally, S.; Tomasicchio, M.; Pooran, A.; Esmail, A.; Kotze, A.; Meier, S.; Wilson, L.; Oelofse, S.; van der Merwe, C.; Roomaney, A. et al.; Davids, M.; Suliman, T.; Joseph, R.; Perumal, T.; Scott, A.; Shaw, M.; Preiser, W.; Williamson, C.; Goga, A.; Mayne, E.; Gray, G.; Moore, P.; Sigal, A.; Limberis, J.; Metcalfe, J.; Dheda, K.: Frequency, kinetics and determinants of viable SARS-CoV-2 in bioaerosols from ambulatory COVID-19 patients infected with the Beta, Delta or Omicron variants. Nature Communications 15 (1), 2003 (2024)
2023
Journal Article
Krause, R. G. E.; Moyo-Gwete, T.; Richardson, S. I.; Makhado, Z.; Manamela, N. P.; Hermanus, T.; Mkhize, N. N.; Keeton, R.; Benede, N.; Mennen, M. et al.; Skelem, S.; Karim, F.; Khan, K.; Riou, C.; Ntusi, N. A. B.; Goga, A.; Gray, G.; Hanekom, W.; Garrett, N.; Bekker, L.-G.; Groll, A.; Sigal, A.; Moore, P. L.; Burgers, W. A.; Leslie, A.: Infection pre-Ad26.COV2.S-vaccination primes greater class switching and reduced CXCR5 expression by SARS-CoV-2-specific memory B cells. NPJ Vaccines 8 (1) (2023)
Journal Article
Naicker, N.; Rodel, H.; Perumal, R.; Ganga, Y.; Bernstein, M.; Benede, N.; Karim, S. A.; Padayacthi, N.; Sigal, A.; Naidoo, K.: Metformin Increases Cell Viability and Regulates Pro-Inflammatory Response to Mtb. Infect Drug Resist, 16:3629-3638 (2023)
Journal Article
Hysenaj, L.; Little, S.; Kulhanek, K.; Magnen, M.; Bahl, K.; Gbenedio, O. M.; Prinz, M.; Rodriguez, L.; Andersen, C.; Rao, A. A. et al.; Shen, A.; Lone, J.-C.; Lupin-Jimenez, L. C.; Bonser, L. R.; Serwas, N. K.; Mick, E.; Khalid, M. M.; Taha, T. Y.; Kumar, R.; Li, J. Z.; Ding, V. W.; Matsumoto, S.; Maishan, M.; Sreekumar, B.; Simoneau, C.; Nazarenko, I.; Tomlinson, M. G.; Khan, K.; von Gottberg, A.; Sigal, A.; Looney, M. R.; Fragiadakis, G. K.; Jablons, D. M.; Langelier, C. R.; Matthay, M.; Krummel, M.; Erle, D. J.; Combes, A. J.; Sil, A.; Ott, M.; Kratz, J. R.; Roose, J. P.: SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants. Stem Cell Reports 18 (3), pp. 636 - 653 (2023)
2022
Journal Article
Tan, C. W.; Chia, W. N.; Zhu, F.; Young, B. E.; Chantasrisawad, N.; Hwa, S.-H.; Yeoh, A. Y.-Y.; Lim, B. L.; Yap, W. C.; Pada, S. K. M. S. et al.; Tan, S. Y.; Jantarabenjakul, W.; Toh, L. K.; Chen, S.; Zhang, J.; Mah, Y. Y.; Chen, V. C.-W.; Chen, M. I.-C.; Wacharapluesadee, S.; Sigal, A.; Putcharoen, O.; Lye, D. C.; Wang, L.-F.: SARS-CoV-2 Omicron variant emerged under immune selection. Nature Microbiology 7 (11), pp. 1756 - 1761 (2022)
Journal Article
Krause, R.; Snyman, J.; Shi-Hsia, H.; Muema, D.; Karim, F.; Ganga, Y.; Ngoepe, A.; Zungu, Y.; Gazy, I.; Bernstein, M. et al.; Khan, K.; Mazibuko, M.; Mthabela, N.; Ramjit, D.; COMMIT-KZN Team; Limbo, O.; Jardine, J.; Sok, D.; Wilson, I. A.; Hanekom, W.; Sigal, A.; Kløverpris, H.; Ndung'u, T.; Leslie, A.: HIV skews the SARS-CoV-2 B cell response towards an extrafollicular maturation pathway. eLife, e79924 (2022)
Journal Article
Snyman, J.; Hwa, S. H.; Krause, R.; Muema, D.; Reddy, T.; Ganga, Y.; Karim, F.; Leslie, A.; Sigal, A.; Ndung'u, T. et al.; COMMIT-KZN Team: Similar Antibody Responses Against Severe Acute Respiratory Syndrome Coronavirus 2 in Individuals Living Without and With Human Immunodeficiency Virus on Antiretroviral Therapy During the First South African Infection Wave. Clinical Infectious Diseases 75 (1) (2022)
Journal Article
Hwa, h.-H.; Snyman, J.; Bernstein, M.; Ganga, Y.; Cele, S.; Muema, D.; Tan, C. W.; Khan, K.; Karim, F.; Hanekom, W. et al.; Bernstein, L.; Kaufmann, S. H. E.; Wang, L.-F.; Ndung’u, T.; Sigal, A.; COMMIT-KZN Team: Association Between Human Immunodeficiency Virus Viremia and compromised Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Beta Variant. The Journal of Infectious Diseases (2022)
Journal Article
Hwa, S.-H.; Snyman, J.; Bernstein, M.; Ganga, Y.; Cele, S.; Muema, D.; Tan, C. W.; Khan, K.; Karim, F.; Hanekom, W. et al.; Bernstein, L.; Kaufmann, S. H. E.; Wang, L.-F.; Ndung'u, T.; Sigal, A.: HIV viremia is associated with compromised SARS-CoV-2 Beta variant neutralization. The Journal of Infectious Diseases (2022)
Journal Article
Khan, K.; Karim, F.; Ganga, Y.; Bernstein, M.; Jule, Z.; Reedoy, K.; Cele, S.; Lustig, G.; Amoako, D.; Wolter, N. et al.; Samsunder, N.; Sivro, A.; San, J. E.; Giandhari, J.; Tegally, H.; Pillay, S.; Naidoo, Y.; Mazibuko, M.; Miya, Y.; Ngcobo, N.; Manickchund, N.; Magula, N.; Karim, Q. A.; von Gottberg, A.; Karim, S. S. A.; Hanekom, W.; Gosnell, B. I.; Team, C.-K.; Lessells, R. J.; de Oliveira, T.; Moosa, M.-Y. S.; Sigal, A.: Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection. Nature Communications 13 (1), 4686 (2022)
Journal Article
Greaney, A. J.; Eguia, R. T.; Starr, T. N.; Khan, K.; Franko, N.; Logue, J. K.; Lord, S. M.; Speake, C.; Chu, H. Y.; Sigal, A. et al.; Bloom, J. D.: The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes. PLoS Pathogens 18 (6), e1010592 (2022)
Journal Article
Khan, K.; Karim, F.; Cele, S.; Reedoy, K.; San, J. E.; Lustig, G.; Tegally, H.; Rosenberg, Y.; Bernstein, M.; Jule, Z. et al.; Ganga, Y.; Ngcobo, N.; Mazibuko, M.; Mthabela, N.; Mhlane, Z.; Mbatha, N.; Miya, Y.; Giandhari, J.; Ramphal, Y.; Naidoo, T.; Sivro, A.; Samsunder, N.; Kharsany, A. B. M.; Amoako, D.; Bhiman, J. N.; Manickchund, N.; Karim, Q. A.; Magula, N.; Karim, S. S. A.; Gray, G.; Hanekom, W.; von Gottberg, A.; Team, C.-K.; Milo, R.; Gosnell, B. I.; Lessells, R. J.; Moore, P. L.; de Olveira, T.; Moosa, M.-Y. S.; Sigal, A.: Omicron infection enhances Delta antibody immunity in vaccinated persons. Nature (2022)
Journal Article
Sigal, A.; Milo, R.; Jassat, W.: Estimating disease severity of Omicron and Delta SARS-CoV-2 infections COMMENT. Nature Reviews Immunology 22 (5), pp. 267 - 269 (2022)
Journal Article
Reuschl, A.-K.; Mesner, D.; Shivkumar, M.; Whelan, M. V. X.; Pallett, L. J.; Guerra-Assunção, J. A.; Madansein, R.; Dullabh, K. J.; Sigal, A.; Thornhill, J. P. et al.; Herrera, C.; Fidler, S.; Noursadeghi, M.; Maini, M. K.; Jolly, C.: HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells. Cell Reports 39 (2), 110650 (2022)
Journal Article
Scheepers, C.; Everatt, J.; Amoako, D. G.; Tegally, H.; Wibmer, C. K.; Mnguni, A.; Ismail, A.; Mahlangu, B.; Lambson, B. E.; Martin, D. P. et al.; Wilkinson, E.; San, J. E.; Giandhari, J.; Manamela, N.; Ntuli, N.; Kgagudi, P.; Cele, S.; Richardson, S. I.; Pillay, S.; Mohale, T.; Ramphal, U.; Naidoo, Y.; Khumalo, Z. T.; Kwatra, G.; Gray, G.; Bekker, L.-G.; Madhi, S. A.; Baillie, V.; Voorhis, W. C. V.; Treurnicht, F. K.; Venter, M.; Mlisana, K.; Wolter, N.; Sigal, A.; Williamson, C.; Hsiao, N.-Y.; Msomi, N.; Maponga, T.; Preiser, W.; Makatini, Z.; Lessells, R.; Moore, P. L.; de Oliveira, T.; von Gottberg, A.; Bhiman, J. N.: Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage. Nature Communications 13 (1), 1976 (2022)
Journal Article
Sigal, A.; Milo, R.; Jassat, W.: Estimating disease severity of Omicron and Delta SARS-CoV-2 infections. Nature Reviews Immunology 22, pp. 267 - 269 (2022)
Journal Article
Cele, S.; Jackson, L.; Khoury, D. S.; Khan, K.; Moyo-Gwete, T.; Tegally, H.; San, J. E.; Cromer, D.; Scheepers, C.; Amoako, D. G. et al.; Karim, F.; Bernstein, M.; Lustig, G.; Archary, D.; Smith, M.; Ganga, Y.; Jule, Z.; Reedoy, K.; Hwa, S.-H.; Giandhari, J.; Blackburn, J. M.; Gosnell, B. I.; Karim, S. S. A.; Hanekom, W.; NGS-SA, COMMIT-KZN Team; von Gottberg, A.; Bhiman, J. N.; Lessells, R. J.; Moosa, M.-Y. S.; Davenport, M. P.; de Oliveira, T.; Moore, P. L.; Sigal, A.: Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization. Nature 602, pp. 654 - 656 (2022)
Journal Article
Cele, S.; Karim, F.; Lustig, G.; San, J. E.; Hermanus, T.; Tegally, H.; Snyman, J.; Moyo-Gwete, T.; Wilkinson, E.; Bernstein, M. et al.; Khan, K.; Hwa, S.-H.; Tilles, S. W.; Singh, L.; Giandhari, J.; Mthabela, N.; Mazibuko, M.; Ganga, Y.; Gosnell, B. I.; Karim, S. S. A.; Hanekom, W.; Voorhis, W. C. V.; Ndung'u, T.; Team, C.-K.; Lessells, R. J.; Moore, P. L.; Moosa, M.-Y. S.; de Oliveira, T.; Sigal, A.: SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape. Cell Host & Microbe 30 (2) (2022)
Journal Article
Meng, B.; Abdullahi, A.; Ferreira, I. A. T. M.; Goonawardane, N.; Saito, A.; Kimura, I.; Yamasoba, D.; Gerber, P. P.; Fatihi, S.; Rathore, S. et al.; Zepeda, S. K.; Papa, G.; Kemp, S. A.; Ikeda, T.; Toyoda, M.; Tan, T. S.; Kuramochi, J.; Mitsunaga, S.; Ueno, T.; Shirakawa, K.; Takaori-Kondo, A.; Brevini, T.; Mallery, D. L.; Charles, O. J.; Collaboration, C.-N. B. C.-; Japan, G. t. P.; Consortium, E.-C.; Bowen, J. E.; Joshi, A.; Walls, A. C.; Jackson, L.; Martin, D.; Smith, K. G. C.; Bradley, J.; Briggs, J. A. G.; Choi, J.; Madissoon, E.; Meyer, K.; Mlcochova, P.; Ceron-Gutierrez, L.; Doffinger, R.; Teichmann, S. A.; Fisher, A. J.; Pizzuto, M. S.; de Marco, A.; Corti, D.; Hosmillo, M.; Lee, J. H.; James, L. C.; Thukral, L.; Veesler, D.; Sigal, A.; Sampaziotis, F.; Goodfellow, I. G.; Matheson, N. J.; Sato, K.; Gupta, R. K.: Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity. Nature 603 (7902), pp. 706 - 714 (2022)
Journal Article
Keeton, R.; Tincho, M. B.; Ngomti, A.; Baguma, R.; Benede, N.; Suzuki, A.; Khan, K.; Cele, S.; Bernstein, M.; Karim, F. et al.; Madzorera, S. V.; Moyo-Gwete, T.; Mennen, M.; Skelem, S.; Adriaanse, M.; Mutithu, D.; Aremu, O.; Stek, C.; du Bruyn, E.; Mescht, M. A. V. D.; de Beer, Z.; de Villiers, T. R.; Bodenstein, A.; van den Berg, G.; Mendes, A.; Strydom, A.; Venter, M.; Giandhari, J.; Naidoo, Y.; Pillay, S.; Tegally, H.; Grifoni, A.; Weiskopf, D.; Sette, A.; Wilkinson, R. J.; de Oliveira, T.; Bekker, L.-G.; Gray, G.; Ueckermann, V.; Rossouw, T.; Boswell, M. T.; Bihman, J.; Moore, P. L.; Sigal, A.; Ntusi, N. A. B.; Burgers, W. A.; Riou, C.: T cell responses to SARS-CoV-2 spike cross-recognize Omicron. Nature 603, pp. 488 - 492 (2022)
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