A SARS-CoV-2 protein interaction map reveals targets for drug repurposing | New Voices in Infection Biology

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Talk abstract:

The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has caused worldwide social and economic disruption. Efforts to treat SARS-CoV-2 have been hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds, and screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents could lead to a therapeutic regimen to treat COVID-19.