Mammalian DNases and their role in the tug of war between Staphylococcus aureus and the host

Voices in Infection Biology

  • Datum: 06.02.2023
  • Uhrzeit: 16:00
  • Vortragende(r): Victor Torres
  • NYU Langone Health
  • Ort: Max Planck Institute for Infection Biology and via Zoom
  • Raum: seminar room 1+2
  • Gastgeber: Arturo Zychlinsky & Gerben Marsman
  • Kontakt:
Mammalian DNases and their role in the tug of war between<i> Staphylococcus aureus</i> and the host

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Mammals contain DNASE1 and DNASE1L3 in serum. While the role of these enzymes in tolerance to self-DNA has been studied, their overall function in immunity is less clear. We discovered that combined deficiency of DNASE1 and DNASE1L3 render mice susceptible to bloodstream infection with the Gram-positive pathogen Staphylococcus aureus. DNASE1/DNASE1L3 double-deficient mice demonstrated severe pathology, increased bacterial burden and lesions containing bacterial extracellular DNA (eDNA) in the kidneys. Both DNASE1 and DNASE1L3 digested DNA-containing S. aureus biofilms in vitro, and the administration of recombinant DNASE1 ameliorated S. aureus-induced disease in mice. Thus, DNASE1 and DNASE1L3 jointly facilitate the control of bacterial infection by digesting microbial eDNA, suggesting an evolutionary function of secreted DNases as antimicrobial agents.

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