Physical phenotyping of cells in biology and medicine
Voices in Infection Biology
- Datum: 15.02.2023
- Uhrzeit: 16:00
- Vortragende(r): Jochen Guck
- Max Planck Institute for the Science of Light
- Ort: Max Planck Institute for Infection Biology and via Zoom
- Raum: seminar room 1+2
- Gastgeber: Simone Reber
- Kontakt: firstname.lastname@example.org
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While most current research in the life sciences focuses on molecular, biochemical aspects of cell processes, we are interested in the emergent physical properties of cells and their importance for biological function. One reason why such properties are not yet generally considered is also a paucity of appropriate tools for their quantification. We are developing novel photonic and microfluidic tools to quantify these physical properties, including real-time deformability cytometry, optical diffraction tomography, and Brillouin microscopy. I will introduce these techniques and explain which quantitative physical properties are being measured. Finally, I will illustrate how this physical phenotyping leads to better understanding of cell function, new insights into nuclear biology, and improved disease diagnosis ranging from malaria infection to Covid19.