Molecular and spatial organization of immune microenvironments in cancer

Voices in Infection Biology

  • Datum: 12.02.2025
  • Uhrzeit: 16:00
  • Vortragende(r): Renato Ostuni
  • San Raffaele Telethon Institute for Gene Therapy
  • Ort: Max Planck Institute for Infection Biology
  • Raum: seminar room 1+2
  • Gastgeber: Arturo Zychlinsky & Alessandro Foti
  • Kontakt: vseminars@mpiib-berlin.mpg.de
Molecular and spatial organization of immune microenvironments in cancer

Abstract:

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer marked by severe immune suppression and abnormal inflammation that promote tumor growth. Recent research identified IL-1b+ tumor-associated macrophages (TAMs) as a subset that drives inflammatory changes and influences nearby tumor cells. Using spatial gene expression analysis we explored the physical distribution and local interactions of IL-1b+ TAMs and within human PDAC tissue. The findings revealed distinct clustering of immune and non-immune cells into specific multicellular hubs, suggesting potential immune-mediated pathways that could be targeted for therapeutic strategies.

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