Deciphering the complexities of malaria immunity using systems-based approaches| New Voices in Infection Biology

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Talk abstract:

The complexity of the Plasmodium life cycle and the host response against the malaria parasite has hampered the development of a highly effective vaccine. Systems-based approaches can provide us with unbiased assessments of the immune response to Plasmodium infection and malaria vaccines to address clinically relevant questions: 1. How do malaria-exposed individuals learn to tolerate parasitemia, sometimes at densities that are lethal in malaria-naïve individuals? 2. Which immune responses induced by either naturally acquired malaria or candidate malaria vaccines are associated with protection from malaria infection and disease? By applying integrated blood transcriptomics and serological profiling to well-characterized cohort studies, we aim to better understand the complex immunological processes that drive disease severity and tolerance and facilitate the identification of immune correlates of protection against malaria.