Microbial pathogens are shaped by their evolutionary history, which provides them the genomic framework to cause disease. The Key lab aims to uncover the genetic mechanisms and phenotypic variation that underlay emergence and adaptation of infectious microbes. Therefore we develop methods to track microbial evolution on dramatically different timescales by leveraging ancient DNA from archaeological specimen as well as high definition genomic data from clinical samples. Understanding the mechanisms of infectious disease emergence and adaptation holds promise to improve disease prevention, intervention and to develop more targeted therapies. More details here
09/2020: Official start of the lab. Stay tuned for updates. Exciting times ahead.
04/2020: The Key lab has two open calls for PhD students part of the IMPRS-IDI grad school. Come and join us to work on exciting and interdisciplinary projects in bacterial genetics! Read more
12/2019: Our paper about HOPS is out in Genome Biology. We present a computational tool that facilitates streamlined identification and authentication of ancient microbial DNA from archaeological remains.